Coyle P, Mathew G, Game P A, Myers J C, Philcox J C, Rofe A M, Jamieson G G
Division of Clinical Biochemistry, Institute of Medical and Veterinary Science, Frome Road, Adelaide, SA 5000 Australia.
Br J Cancer. 2002 Aug 27;87(5):533-6. doi: 10.1038/sj.bjc.6600473.
The potential of the metal-binding protein, metallothionein, in assessing the progression of normal oesophagus through Barrett's to adenocarcinoma was investigated. Metallothionein was quantitatively determined in resected tissues from patients undergoing oesophagectomy for high grade dysplasia/adenocarcinoma and in biopsies from patients with Barrett's syndrome. In 10 cancer patients, metallothionein concentrations in adenocarcinoma were not significantly different from normal oesophagus, although six had elevated metallothionein concentrations in the metaplastic tissue bordering the adenocarcinoma. In 17 out of 20 non-cancer patients with Barrett's epithelium, metallothionein was significantly increased by 108% (P<0.004). There was no association between the metallothionein levels in Barrett's epithelium and the presence of inflammatory cells, metaplasia or dysplasia. Metallothionein is a marker of progression from normal to Barrett's epithelium but is not increased in oesophageal adenocarcinoma.
研究了金属结合蛋白金属硫蛋白在评估正常食管经巴雷特食管发展为腺癌过程中的潜力。对因高级别发育异常/腺癌接受食管切除术患者的切除组织以及巴雷特综合征患者的活检组织进行了金属硫蛋白的定量测定。在10例癌症患者中，腺癌中的金属硫蛋白浓度与正常食管无显著差异，尽管有6例患者腺癌周围化生组织中的金属硫蛋白浓度升高。在20例非癌症的巴雷特上皮患者中，有17例的金属硫蛋白显著增加了108%（P<0.004）。巴雷特上皮中的金属硫蛋白水平与炎症细胞、化生或发育异常的存在之间没有关联。金属硫蛋白是从正常食管发展为巴雷特上皮的标志物，但在食管腺癌中不会升高。
