Takuma T, Okada K, Uchida Y, Yamagata A, Sawae Y
Medicine and Biosystemic Science, Kyushu University Graduate School of Sciences, Fukuoka, Japan.
J Intern Med. 2002 Aug;252(2):173-7. doi: 10.1046/j.1365-2796.2002.01012.x.
Respiratory failure is a severe complication of invasive pulmonary aspergillosis (IPA). Its pathogenesis is not well understood. We herein describe three cases of subacute respiratory failure that occurred during the recovery phase of neutropenia following induction chemotherapy for acute leukaemia with IPA. In each case, severe neutropenia (19-85 days), high-grade fever, severe anaemia, the use of granulocyte-colony-stimulating factor and increasing infusion volume were noted. As the neutrophil count was recovering, the shadows on the chest X-ray expanded with progressing hypoxia. We should pay attention to the respiratory failure during the recovery phase of neutropenia in patients with IPA.
呼吸衰竭是侵袭性肺曲霉病（IPA）的一种严重并发症。其发病机制尚不清楚。我们在此描述了3例急性白血病诱导化疗合并IPA患者在中性粒细胞减少恢复期发生的亚急性呼吸衰竭病例。每例患者均出现严重中性粒细胞减少（19 - 85天）、高热、严重贫血、使用粒细胞集落刺激因子以及输液量增加。随着中性粒细胞计数恢复，胸部X线阴影扩大，同时缺氧情况加重。对于IPA患者，我们应关注其在中性粒细胞减少恢复期的呼吸衰竭情况。
