来自马来西亚药用植物斯科氏腐木属（茜草科）的环烯醚萜类化合物和蒽醌类化合物

Iridoids and anthraquinones from the Malaysian medicinal plant, Saprosma scortechinii (Rubiaceae).

作者信息

Ling Sui-Kiong, Komorita Akiko, Tanaka Takashi, Fujioka Toshihiro, Mihashi Kunihide, Kouno Isao

机构信息

Course of Pharmaceutical Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.

出版信息

Chem Pharm Bull (Tokyo). 2002 Aug;50(8):1035-40. doi: 10.1248/cpb.50.1035.

DOI:10.1248/cpb.50.1035

PMID:12192133

Abstract

A further investigation of the leaves and stems of Saprosma scortechinii afforded 13 compounds, of which 10 are new compounds. These were elucidated as the bis-iridoid glucosides, saprosmosides G (1) and H (2), the iridoid glucoside, 6-O-epi-acetylscandoside (3), and the anthraquinones, 1-methoxy-3-hydroxy-2-carbomethoxy-9,10-anthraquinone (4), 1-methoxy-3-hydroxy-2-carbomethoxy-9,10-anthraquinone 3-O-beta-primeveroside (5), 1,3-dihydroxy-2-carbomethoxy-9,10-anthraquinone 3-O-beta-primeveroside (6), 1,3,6-trihydroxy-2-methoxymethyl-9,10-anthraquinone (7), 1-methoxy-3,6-dihydroxy-2-hydroxymethyl-9,10-anthraquinone (8), 1,3,6-trihydroxy-2-hydroxymethyl-9,10-anthraquinone 3-O-beta-primeveroside (9), and 3,6-dihydroxy-2-hydroxymethyl-9,10-anthraquinone (10). Structure assignments for all compounds were established by means of mass and NMR spectroscopies, chemical methods, and comparison with published data. The new anthraquinones were derivatives of munjistin and lucidin.

摘要

对锡金苦树的叶和茎进行的进一步研究得到了13种化合物，其中10种为新化合物。这些化合物被鉴定为双环烯醚萜苷类，锡金苦树苷G（1）和H（2），环烯醚萜苷，6-O-表-乙酰 scandoside（3），以及蒽醌类，1-甲氧基-3-羟基-2-甲氧基羰基-9,10-蒽醌（4），1-甲氧基-3-羟基-2-甲氧基羰基-9,10-蒽醌3-O-β-樱草糖苷（5），1,3-二羟基-2-甲氧基羰基-9,10-蒽醌3-O-β-樱草糖苷（6），1,3,6-三羟基-2-甲氧基甲基-9,10-蒽醌（7），1-甲氧基-3,6-二羟基-2-羟甲基-9,10-蒽醌（8），1,3,6-三羟基-2-羟甲基-9,10-蒽醌3-O-β-樱草糖苷（9），以及3,6-二羟基-2-羟甲基-9,10-蒽醌（10）。所有化合物的结构归属均通过质谱和核磁共振光谱、化学方法以及与已发表数据的比较得以确定。新的蒽醌类是芒柄花素和卢西定的衍生物。