Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, Hainan, China.
Molecules. 2013 Nov 25;18(12):14496-504. doi: 10.3390/molecules181214496.
Three new ursane-type triterpenoids, 3α,6α,30-trihydroxy-ursan-28-oic acid (1), 3α,30-dihydroxy-6-oxo-ursan-28-oic acid (2) and 3α,6α,7α,30-tetrahydroxy-ursan-28-oic acid (3), together with one known triterpenoid, betulinic acid (4), one known anthraquinone, 1,7-dihydroxy-2-methylanthraquinone (5), four known phenols, 1,3,5-trimethoxybenzene (6), p-hydroxybenzoic acid (7), syringic acid (8), isovanillin (9), two steroids, sitosterol (10) and daucosterol (11), were isolated from the ethanol extract of the stems of S. merrillii. Their structures were elucidated on the basis of physical and spectral techniques, besides comparison with literature data. Compounds 1-3 showed inhibitory activities against the A549, HEPG2, and B16F10 cell lines.
从中国菝葜茎的乙醇提取物中分离得到了三种新的五环三萜类化合物，分别为 3α,6α,30-三羟基乌苏烷-28-酸（1）、3α,30-二羟基-6-酮基乌苏烷-28-酸（2）和 3α,6α,7α,30-四羟基乌苏烷-28-酸（3），以及一种已知的三萜类化合物白桦脂酸（4）、一种已知的蒽醌类化合物 1,7-二羟基-2-甲基蒽醌（5）、四种已知的酚类化合物 1,3,5-三甲氧基苯（6）、对羟基苯甲酸（7）、丁香酸（8）、异香草醛（9）、两种甾体化合物豆甾醇（10）和胡萝卜苷（11）。根据物理和光谱技术，并与文献数据进行比较，确定了它们的结构。化合物 1-3 对 A549、HEPG2 和 B16F10 细胞系具有抑制活性。
