儿童胃肠道疾病与自闭症的关系：利用英国全科医学研究数据库的数据进行巢式病例对照研究。
Relation of childhood gastrointestinal disorders to autism: nested case-control study using data from the UK General Practice Research Database.
作者信息
Black Corri, Kaye James A, Jick Hershel
机构信息
Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, MA 02421, USA.
出版信息
BMJ. 2002 Aug 24;325(7361):419-21. doi: 10.1136/bmj.325.7361.419.
OBJECTIVES
To assess whether children with autism are more likely to have a history of gastrointestinal disorders than children without autism.
DESIGN
Nested case-control study.
SETTING
UK General Practice Research Database.
SUBJECTS
Children born after 1 January 1988 and registered with the General Practice Research Database within 6 months of birth.
OUTCOME MEASURES
Chronic inflammation of the gastrointestinal tract, coeliac disease, food intolerance, and recurrent gastrointestinal symptoms recorded by the general practitioner.
RESULTS
9 of 96 (9%) children with a diagnosis of autism (cases) and 41 of 449 (9%) children without autism (matched controls) had a history of gastrointestinal disorders before the index date (the date of first recorded diagnosis of autism in the cases and the same date for controls). The estimated odds ratio for a history of gastrointestinal disorders among children with autism compared with children without autism was 1.0 (95% confidence interval 0.5 to 2.2).
CONCLUSIONS
No evidence was found that children with autism were more likely than children without autism to have had defined gastrointestinal disorders at any time before their diagnosis of autism.
目的
评估与无自闭症的儿童相比，自闭症儿童是否更有可能有胃肠道疾病史。
设计
巢式病例对照研究。
设置
英国全科医疗研究数据库。
研究对象
1988年1月1日后出生且在出生后6个月内登记到全科医疗研究数据库的儿童。
观察指标
全科医生记录的胃肠道慢性炎症、乳糜泻、食物不耐受和反复出现的胃肠道症状。
结果
96例被诊断为自闭症的儿童（病例组）中有9例（9%），449例无自闭症的儿童（匹配对照组）中有41例（9%）在索引日期（病例组首次记录自闭症诊断的日期，对照组为相同日期）之前有胃肠道疾病史。自闭症儿童与无自闭症儿童相比，有胃肠道疾病史的估计比值比为1.0（95%置信区间0.5至2.2）。
结论
未发现证据表明自闭症儿童在被诊断为自闭症之前的任何时候比无自闭症儿童更有可能患有特定的胃肠道疾病。
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