Molloy Cynthia A, Manning-Courtney Patricia
Center for Epidemiology and Biostatistics, Cincinnati Children's Hospital Medical Center, OH 45229-3039, USA.
Autism. 2003 Jun;7(2):165-71. doi: 10.1177/1362361303007002004.
The purpose of this study was to estimate the prevalence of chronic gastrointestinal symptoms in a general population of children with autism or autistic spectrum disorder (ASD). The study site was a clinic specializing in ASD in a large pediatric medical center serving a 10 county area in the midwestern USA. In a sample of 137 children, age 24-96 months, classified as having autism or ASD by the Autism Diagnostic Observation Schedule-Generic, 24 percent had a history of at least one chronic gastrointestinal symptom. The most common symptom was diarrhea, which occurred in 17 percent. There was no association between chronic gastrointestinal symptoms and a history of developmental regression. The potential phenotypic association between autism and gastrointestinal symptoms is discussed.
本研究的目的是估计患有自闭症或自闭症谱系障碍（ASD）的儿童普通人群中慢性胃肠道症状的患病率。研究地点是美国中西部一个为10个县地区服务的大型儿科医疗中心的一家专门治疗ASD的诊所。在137名年龄在24至96个月之间、根据《自闭症诊断观察量表通用版》被分类为患有自闭症或ASD的儿童样本中，24%的儿童有至少一种慢性胃肠道症状史。最常见的症状是腹泻，发生率为17%。慢性胃肠道症状与发育倒退史之间没有关联。讨论了自闭症与胃肠道症状之间潜在的表型关联。
