Peltoniemi Hilkka, Ashammakhi Nureddin, Kontio Risto, Waris Timo, Salo Antero, Lindqvist Christian, Grätz Klaus, Suuronen Riitta
Department of Plastic Surgery, Helsinki University Central Hospital, Helsinki, Finland.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002 Jul;94(1):5-14. doi: 10.1067/moe.2002.122160.
Because of problems associated with the conventional osteofixation devices used in craniomaxillofacial surgery, bioabsorbable devices have presented an appealing alternative. Devices made of the polymers polyglycolide (PGA) and polylactide (PLA) and their copolymers (PLGA and PLDLA) are currently the most commonly used. Strong implants can be manufactured from these polymers with a self-reinforcing technique and used in the treatment of fractures and osteotomies. Self-reinforced devices have been studied for nearly 2 decades by our multidisciplinary research group for internal fixation of the bone in both experimental and clinical settings. In craniomaxillofacial fractures and osteotomies they have been used for as long as 10 years with no significant clinical problems. Because of more favored degradation characteristics, currently the copolymer devices (PLDLA and PLGA) represent the advancing front in the application of absorbable devices in craniomaxillofacial surgery. By using bioabsorbable devices, several problems associated with conventional biostable devices can be avoided, especially in children. New techniques that are not possible with biostable devices can be developed by using bioabsorbable devices, too. Our experience with and research on self-reinforced devices are shared here.
由于颅颌面外科手术中使用的传统骨固定装置存在问题,生物可吸收装置成为了一种有吸引力的替代方案。由聚乙交酯(PGA)、聚丙交酯(PLA)及其共聚物(PLGA和PLDLA)制成的装置是目前最常用的。利用自增强技术可以用这些聚合物制造出坚固的植入物,用于治疗骨折和截骨术。我们的多学科研究小组在实验和临床环境中对自增强装置用于骨内固定进行了近20年的研究。在颅颌面骨折和截骨术中,它们已经使用了长达10年,没有出现重大临床问题。由于具有更有利的降解特性,目前共聚物装置(PLDLA和PLGA)代表了可吸收装置在颅颌面外科手术应用中的前沿进展。通过使用生物可吸收装置,可以避免一些与传统生物稳定装置相关的问题,尤其是在儿童中。使用生物可吸收装置也可以开发出一些生物稳定装置无法实现的新技术。在此分享我们对自增强装置的经验和研究。