Hsu C, Leighton H J, Westfall T C, Brooker G
J Cyclic Nucleotide Res. 1976 Sep-Oct;2(5):359-64.
Decentralization of the guinea pig vas deferens resulted in supersensitivity of the contractile response to methacholine. Methacholine also elevated cyclic GMP to a greater extent in the decentralized vas deferens than in sham-operated controls. Decentralization did not alter basal cyclic AMP or cyclic GMP content. These observations are analogous to the enhanced responsiveness of cyclic AMP formation in supersensitive beta adrenergic systems.
豚鼠输精管去神经支配导致对乙酰甲胆碱的收缩反应超敏。与假手术对照组相比，乙酰甲胆碱在去神经支配的输精管中也能更大程度地提高环鸟苷酸（cGMP）水平。去神经支配并未改变基础环磷酸腺苷（cAMP）或环鸟苷酸含量。这些观察结果类似于超敏β肾上腺素能系统中环磷酸腺苷生成的反应性增强。
