Ribeiro Jose M C, Francischetti Ivo M B
Medical Entomology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 4 Center Drive, Bethesda, Maryland, 20892-0425, USA.
Annu Rev Entomol. 2003;48:73-88. doi: 10.1146/annurev.ento.48.060402.102812. Epub 2002 Jun 4.
This review addresses the problems insects and ticks face to feed on blood and the solutions these invertebrates engender to overcome these obstacles, including a sophisticated salivary cocktail of potent pharmacologic compounds. Recent advances in transcriptome and proteome research allow an unprecedented insight into the complexity of these compounds, indicating that their molecular diversity as well as the diversity of their targets is still larger than previously thought.
本综述探讨了昆虫和蜱虫在以血液为食时所面临的问题，以及这些无脊椎动物为克服这些障碍所产生的解决方案，包括一种由强效药理化合物组成的复杂唾液混合物。转录组和蛋白质组研究的最新进展使人们对这些化合物的复杂性有了前所未有的深入了解，表明它们的分子多样性以及靶点的多样性仍比以前认为的要大。
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