Deng Yuan-Ping, Fu Yi-Tian, Elsheikha Hany M, Cao Mei-Ling, Zhu Xing-Quan, Wang Jin-Lei, Zhang Xue-Ling, Xie Shi-Chen, Yao Chaoqun, Liu Guo-Hua
Research Center for Parasites and Vectors, College of Veterinary Medicine, Hunan Agricultural University, Changsha, Hunan, China.
Department of Parasitology, Xiangya School of Basic Medicine, Central South University, Changsha, Hunan, China.
Clin Microbiol Rev. 2024 Dec 10;37(4):e0007424. doi: 10.1128/cmr.00074-24. Epub 2024 Oct 23.
SUMMARYTick paralysis is a potentially fatal condition caused by neurotoxins secreted by the salivary glands of certain ticks. Documented cases have been reported worldwide, predominantly in the United States, Canada, and Australia, with additional reports from Europe and Africa. This condition also affects animals, leading to significant economic losses and adverse impacts on animal health and welfare. To date, 75 tick species, mostly hard ticks, have been identified as capable of causing this life-threatening condition. Due to symptom overlap with other conditions, accurate diagnosis of tick paralysis is crucial to avoid misdiagnosis, which could result in adverse patient outcomes. This review provides a comprehensive analysis of the current literature on tick paralysis, including the implicated tick species, global distribution, tick toxins, molecular pathogenesis, clinical manifestations, diagnosis, treatment, control, and prevention. Enhancing awareness among medical and veterinary professionals is critical for improving the management of tick paralysis and its health impacts on both humans and animals.
摘要蜱瘫痪是一种由某些蜱的唾液腺分泌的神经毒素引起的潜在致命疾病。世界各地均有病例报告，主要集中在美国、加拿大和澳大利亚，欧洲和非洲也有相关报道。这种疾病也会影响动物，导致重大经济损失，并对动物健康和福利产生不利影响。迄今为止，已确定75种蜱，其中大多数为硬蜱，能够引发这种危及生命的疾病。由于症状与其他疾病重叠，准确诊断蜱瘫痪对于避免误诊至关重要，误诊可能会导致患者出现不良后果。本综述对当前关于蜱瘫痪的文献进行了全面分析，包括涉及的蜱种、全球分布、蜱毒素、分子发病机制、临床表现、诊断、治疗、控制和预防。提高医学和兽医专业人员的认识对于改善蜱瘫痪的管理及其对人类和动物健康的影响至关重要。
