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A new name in thrombosis, ADAMTS13.血栓形成领域的一个新名称：ADAMTS13。
Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11552-4. doi: 10.1073/pnas.192448999. Epub 2002 Aug 23.
2
[From gene to disease; congenital thrombotic thrombocytopenic purpura due to mutations in the ADAMTS13 gene].从基因到疾病；因ADAMTS13基因突变导致的先天性血栓性血小板减少性紫癜
Ned Tijdschr Geneeskd. 2003 Dec 6;147(49):2422-4.
3
Structural and functional correlation of ADAMTS13.ADAMTS13的结构与功能相关性
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4
Von Willebrand factor, ADAMTS13, and thrombotic thrombocytopenic purpura.血管性血友病因子、ADAMTS13与血栓性血小板减少性紫癜
J Mol Med (Berl). 2002 Oct;80(10):639-47. doi: 10.1007/s00109-002-0369-8. Epub 2002 Sep 5.
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ADAMTS 13 genotype and vWF protease activity in an Italian family with TTP.
Thromb Haemost. 2003 Nov;90(5):955-6. doi: 10.1160/TH03-03-0150.
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Keeping von Willebrand Factor under Control: Alternatives for ADAMTS13.控制血管性血友病因子：ADAMTS13的替代方案
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7
von Willebrand factor-cleaving protease in thrombotic thrombocytopenic purpura and the hemolytic-uremic syndrome.血栓性血小板减少性紫癜和溶血尿毒综合征中的血管性血友病因子裂解蛋白酶
N Engl J Med. 1998 Nov 26;339(22):1578-84. doi: 10.1056/NEJM199811263392202.
8
Molecular mechanisms in thrombotic thrombocytopenic purpura.血栓性血小板减少性紫癜的分子机制
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9
Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura.ADAMTS基因家族成员的突变会导致血栓性血小板减少性紫癜。
Nature. 2001 Oct 4;413(6855):488-94. doi: 10.1038/35097008.
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Platelet activation and the formation of the platelet plug: deficiency of ADAMTS13 causes thrombotic thrombocytopenic purpura.血小板活化与血小板凝块的形成：ADAMTS13缺乏导致血栓性血小板减少性紫癜。
Arterioscler Thromb Vasc Biol. 2003 Mar 1;23(3):388-96. doi: 10.1161/01.ATV.0000058401.34021.D4. Epub 2003 Jan 30.

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Immune thrombotic thrombocytopenic purpura: pathogenesis and novel therapies: a narrative review.免疫性血栓性血小板减少性紫癜：发病机制与新疗法：一篇叙述性综述
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Targeting neutrophil extracellular trap accumulation under flow in patients with immune-mediated thrombotic thrombocytopenic purpura.靶向免疫介导性血栓性血小板减少性紫癜患者血流中中性粒细胞胞外诱捕网的积聚。
Blood Adv. 2024 May 28;8(10):2536-2551. doi: 10.1182/bloodadvances.2023011617.
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Goblet cell interactions reorient bundled mucus strands for efficient airway clearance.杯状细胞相互作用重新定向束状黏液丝以实现有效的气道清除。
PNAS Nexus. 2023 Nov 10;2(11):pgad388. doi: 10.1093/pnasnexus/pgad388. eCollection 2023 Nov.
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Dynamic Assessment of Plasma von Willebrand Factor and ADAMTS13 Predicts Mortality in Hospitalized Patients with SARS-CoV-2 Infection.血浆血管性血友病因子和含血小板解聚蛋白及金属蛋白酶13的动态评估可预测新型冠状病毒肺炎住院患者的死亡率
J Clin Med. 2023 Nov 19;12(22):7174. doi: 10.3390/jcm12227174.
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ADAMTS13 Biomarkers in Management of Immune Thrombotic Thrombocytopenic Purpura.ADAMTS13 标志物在免疫性血栓性血小板减少性紫癜治疗中的应用。
Arch Pathol Lab Med. 2023 Aug 1;147(8):974-979. doi: 10.5858/arpa.2022-0050-RA.
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Low ADAMTS-13 predicts adverse outcomes in hospitalized patients with suspected heparin-induced thrombocytopenia.低ADAMTS-13水平预示着疑似肝素诱导的血小板减少症住院患者的不良预后。
Res Pract Thromb Haemost. 2021 Sep 16;5(6):e12581. doi: 10.1002/rth2.12581. eCollection 2021 Aug.
7
ADAMTS13 ameliorates inflammatory responses in experimental autoimmune encephalomyelitis.ADAMTS13 可改善实验性自身免疫性脑脊髓炎的炎症反应。
J Neuroinflammation. 2020 Feb 19;17(1):67. doi: 10.1186/s12974-020-1713-z.
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Clinical factors and biomarkers predict outcome in patients with immune-mediated thrombotic thrombocytopenic purpura.临床因素和生物标志物可预测免疫性血栓性血小板减少性紫癜患者的结局。
Haematologica. 2019 Jan;104(1):166-175. doi: 10.3324/haematol.2018.198275. Epub 2018 Aug 31.
9
Margination and stretching of von Willebrand factor in the blood stream enable adhesion.血管中 von Willebrand 因子的边缘和伸展使黏附得以发生。
Sci Rep. 2017 Oct 27;7(1):14278. doi: 10.1038/s41598-017-14346-4.
10
Mutation G1629E Increases von Willebrand Factor Cleavage via a Cooperative Destabilization Mechanism.G1629E突变通过协同失稳机制增加血管性血友病因子的裂解。
Biophys J. 2017 Jan 10;112(1):57-65. doi: 10.1016/j.bpj.2016.11.3202.

本文引用的文献

1
Studies on thrombopoiesis. I. A factor in normal human plasma required for platelet production; chronic thrombocytopenia due to its deficiency.血小板生成的研究。I. 正常人体血浆中血小板生成所需的一种因子；因该因子缺乏导致的慢性血小板减少症。
Blood. 1960 Jul;16:943-57.
2
ADAMTS-13 rapidly cleaves newly secreted ultralarge von Willebrand factor multimers on the endothelial surface under flowing conditions.ADAMTS-13在流动条件下能迅速切割内皮表面新分泌的超大血管性血友病因子多聚体。
Blood. 2002 Dec 1;100(12):4033-9. doi: 10.1182/blood-2002-05-1401. Epub 2002 Jul 25.
3
Mutations and common polymorphisms in ADAMTS13 gene responsible for von Willebrand factor-cleaving protease activity.负责血管性血友病因子裂解蛋白酶活性的ADAMTS13基因中的突变和常见多态性。
Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11902-7. doi: 10.1073/pnas.172277399. Epub 2002 Aug 14.
4
Complete defect in vWF-cleaving protease activity associated with increased shear-induced platelet aggregation in thrombotic microangiopathy.
Thromb Haemost. 2002 May;87(5):808-11.
5
Ultralarge multimers of von Willebrand factor form spontaneous high-strength bonds with the platelet glycoprotein Ib-IX complex: studies using optical tweezers.血管性血友病因子的超大聚合物与血小板糖蛋白Ib-IX复合物形成自发的高强度键：使用光镊的研究。
Blood. 2002 Jun 1;99(11):3971-7. doi: 10.1182/blood-2001-11-0060.
6
Plasma of patients with Upshaw-Schulman syndrome, a congenital deficiency of von Willebrand factor-cleaving protease activity, enhances the aggregation of normal platelets under high shear stress.患有乌-舒综合征（一种先天性血管性血友病因子裂解蛋白酶活性缺乏症）的患者血浆，在高剪切应力下会增强正常血小板的聚集。
Br J Haematol. 2001 Dec;115(4):991-7. doi: 10.1046/j.1365-2141.2001.03222.x.
7
Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura.ADAMTS基因家族成员的突变会导致血栓性血小板减少性紫癜。
Nature. 2001 Oct 4;413(6855):488-94. doi: 10.1038/35097008.
8
A novel human metalloprotease synthesized in the liver and secreted into the blood: possibly, the von Willebrand factor-cleaving protease?一种在肝脏中合成并分泌到血液中的新型人类金属蛋白酶：它可能是血管性血友病因子裂解蛋白酶吗？
J Biochem. 2001 Oct;130(4):475-80. doi: 10.1093/oxfordjournals.jbchem.a003009.
9
Structure of von Willebrand factor-cleaving protease (ADAMTS13), a metalloprotease involved in thrombotic thrombocytopenic purpura.血管性血友病因子裂解蛋白酶（ADAMTS13）的结构，一种参与血栓性血小板减少性紫癜的金属蛋白酶。
J Biol Chem. 2001 Nov 2;276(44):41059-63. doi: 10.1074/jbc.C100515200. Epub 2001 Sep 13.
10
Purification of human von Willebrand factor-cleaving protease and its identification as a new member of the metalloproteinase family.人血管性血友病因子裂解蛋白酶的纯化及其作为金属蛋白酶家族新成员的鉴定。
Blood. 2001 Sep 15;98(6):1662-6. doi: 10.1182/blood.v98.6.1662.

A new name in thrombosis, ADAMTS13.

作者信息

Sadler J Evan

机构信息

Department of Medicine and Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, MO 63110, USA.

出版信息

Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11552-4. doi: 10.1073/pnas.192448999. Epub 2002 Aug 23.

DOI:10.1073/pnas.192448999
PMID:12195022
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC129303/
Abstract
摘要