A new name in thrombosis, ADAMTS13.
作者信息
Sadler J Evan
机构信息
Department of Medicine and Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, MO 63110, USA.
出版信息
Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11552-4. doi: 10.1073/pnas.192448999. Epub 2002 Aug 23.
Abstract
摘要
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本文引用的文献
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ADAMTS-13 rapidly cleaves newly secreted ultralarge von Willebrand factor multimers on the endothelial surface under flowing conditions.ADAMTS-13在流动条件下能迅速切割内皮表面新分泌的超大血管性血友病因子多聚体。
Blood. 2002 Dec 1;100(12):4033-9. doi: 10.1182/blood-2002-05-1401. Epub 2002 Jul 25.
3
Mutations and common polymorphisms in ADAMTS13 gene responsible for von Willebrand factor-cleaving protease activity.负责血管性血友病因子裂解蛋白酶活性的ADAMTS13基因中的突变和常见多态性。
Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11902-7. doi: 10.1073/pnas.172277399. Epub 2002 Aug 14.
4
Complete defect in vWF-cleaving protease activity associated with increased shear-induced platelet aggregation in thrombotic microangiopathy.
Thromb Haemost. 2002 May;87(5):808-11.
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Ultralarge multimers of von Willebrand factor form spontaneous high-strength bonds with the platelet glycoprotein Ib-IX complex: studies using optical tweezers.血管性血友病因子的超大聚合物与血小板糖蛋白Ib-IX复合物形成自发的高强度键：使用光镊的研究。
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Plasma of patients with Upshaw-Schulman syndrome, a congenital deficiency of von Willebrand factor-cleaving protease activity, enhances the aggregation of normal platelets under high shear stress.患有乌-舒综合征（一种先天性血管性血友病因子裂解蛋白酶活性缺乏症）的患者血浆，在高剪切应力下会增强正常血小板的聚集。
Br J Haematol. 2001 Dec;115(4):991-7. doi: 10.1046/j.1365-2141.2001.03222.x.
7
Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura.ADAMTS基因家族成员的突变会导致血栓性血小板减少性紫癜。
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8
A novel human metalloprotease synthesized in the liver and secreted into the blood: possibly, the von Willebrand factor-cleaving protease?一种在肝脏中合成并分泌到血液中的新型人类金属蛋白酶：它可能是血管性血友病因子裂解蛋白酶吗？
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9
Structure of von Willebrand factor-cleaving protease (ADAMTS13), a metalloprotease involved in thrombotic thrombocytopenic purpura.血管性血友病因子裂解蛋白酶（ADAMTS13）的结构，一种参与血栓性血小板减少性紫癜的金属蛋白酶。
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Purification of human von Willebrand factor-cleaving protease and its identification as a new member of the metalloproteinase family.人血管性血友病因子裂解蛋白酶的纯化及其作为金属蛋白酶家族新成员的鉴定。
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