Zhao Haiying, Morimoto Tadaoki, Sasa Mitsunori, Asato Yutaka, Izumi Keisuke
Department of General Surgery, Second Affiliated Hospital, China Medical University, China.
Breast Cancer. 2002;9(1):86-90. doi: 10.1007/BF02967553.
Mucocele-like lesions (MLL) of the breast have been reported as extremely rare as well as benign, but now it is believed they can be both malignant and benign. This paper describes two cases of malignant MLL, both subjected to immunohistochemical staining. Case 1: A 42-year-old woman with multiple malignant MLLs without evidence of a mass at presentation to our hospital after biopsy, but whose ultrasonogram showed small multiple hypoechoic lesions. Case 2: A 70-year-old woman, whose left breast cancer was found on routine mammography after modified radical mastectomy for right breast cancer. Pathologically, MLL with intraductal carcinoma was diagnosed. Case 1 underwent two lumpectomies in 3 years, but even now new lesions have developed. However, the patient refused to have another operation. C-erbB2 was negative in both cases. When malignant MLL is histologically of low grade, excisional biopsy is sufficient for a single MLL with intraductal carcinoma, while it may be necessary to perform a subcutaneous mastectomy for multiple lesions.
乳腺黏液囊肿样病变（MLL）已被报道极为罕见且为良性，但现在人们认为它们可能是恶性的，也可能是良性的。本文描述了两例恶性MLL病例，均进行了免疫组织化学染色。病例1：一名42岁女性，有多发性恶性MLL，活检后就诊于我院时无肿块迹象，但其超声检查显示有多个小的低回声病变。病例2：一名70岁女性，在右乳癌改良根治术后常规乳腺钼靶检查时发现左乳癌。病理诊断为伴有导管内癌的MLL。病例1在3年内接受了两次肿块切除术，但即使现在仍有新病变出现。然而，患者拒绝再次手术。两例病例的C-erbB2均为阴性。当恶性MLL在组织学上为低级别时，对于单个伴有导管内癌的MLL，切除活检就足够了，而对于多个病变可能需要进行皮下乳房切除术。
