Khalifa A M, Ibrahim I R, el-Kerdany E D
Department of Parasitology, Faculty of Medicine, University of Alexandria, Alexandria, Egypt.
East Mediterr Health J. 2000 Sep-Nov;6(5-6):908-18.
Cryptosporidiosis and toxoplasmosis are diseases caused by opportunistic coccidial parasites that can lead to life-threatening infection in immunocompromised patients. We evaluated dehydroepiandrosterone as prophylaxis and therapy in immunosuppressed mice infected with Cryptosporidium parvum and avirulent Toxoplasma gondii. Mice were infected with either Cryptosporidium oocysts or Toxoplasma cysts. Assessment was by mortality rates, parasitic counts and electron microscopic studies. Mortality rates were significantly reduced in all treated groups. A significant reduction in the cryptosporidial oocyst count in stool and intestinal villi and in Toxoplasma cysts in the brains of infected mice was observed in all the groups. The effect of the drug was greater when given prior to infection.
隐孢子虫病和弓形虫病是由机会性球虫寄生虫引起的疾病，可导致免疫功能低下患者发生危及生命的感染。我们评估了脱氢表雄酮对感染微小隐孢子虫和无毒力弓形虫的免疫抑制小鼠的预防和治疗作用。小鼠分别感染隐孢子虫卵囊或弓形虫囊肿。通过死亡率、寄生虫计数和电子显微镜研究进行评估。所有治疗组的死亡率均显著降低。在所有组中均观察到，感染小鼠粪便和肠绒毛中的隐孢子虫卵囊计数以及脑中的弓形虫囊肿数量显著减少。在感染前给予该药物时，其效果更佳。
