Rehg J E
Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
J Parasitol. 1996 Feb;82(1):158-62.
Diethyldithiocarbamate was the only immune modulator of 7 evaluated to show activity against Cryptosporidium parvum in immunosuppressed rats. The model was then used to assess the drug's activity further. When administered prophylactically, oral doses > or = 75 mg/kg/day significantly (P < or = 0.05) reduced the severity of ileal infection and doses > or = 300 mg/kg/day significantly (P < or = 0.05) inhibited infection of the biliary tract. When administered to rats with established infection, the drug significantly (P < or = 0.05) reduced the parasite burden in the ileum but was ineffective against biliary tract infection. The data suggest that diethyldithiocarbamate is effective for treating cryptosporidiosis of the small intestine but is probably ineffective against chronic cryptosporidiosis involving the large intestine or biliary tract.
二乙氨基二硫代甲酸盐是所评估的7种免疫调节剂中唯一一种在免疫抑制大鼠中显示出抗微小隐孢子虫活性的药物。然后该模型被用于进一步评估该药物的活性。预防性给药时，口服剂量≥75毫克/千克/天可显著（P≤0.05）减轻回肠感染的严重程度，剂量≥300毫克/千克/天可显著（P≤0.05）抑制胆道感染。给已感染的大鼠给药时，该药物可显著（P≤0.05）降低回肠中的寄生虫负荷，但对胆道感染无效。数据表明，二乙氨基二硫代甲酸盐对治疗小肠隐孢子虫病有效，但可能对涉及大肠或胆道的慢性隐孢子虫病无效。
