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Recurrent patterns of DNA methylation in the ZNF154, CASP8, and VHL promoters across a wide spectrum of human solid epithelial tumors and cancer cell lines.在广泛的人类实体上皮肿瘤和癌细胞系中，ZNF154、CASP8 和 VHL 启动子中的 DNA 甲基化的反复模式。
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本文引用的文献

1
Sensitization for death receptor- or drug-induced apoptosis by re-expression of caspase-8 through demethylation or gene transfer.通过去甲基化或基因转移重新表达半胱天冬酶-8使死亡受体或药物诱导的细胞凋亡致敏。
Oncogene. 2001 Sep 13;20(41):5865-77. doi: 10.1038/sj.onc.1204750.
2
Death receptor recruitment of endogenous caspase-10 and apoptosis initiation in the absence of caspase-8.在缺乏半胱天冬酶-8的情况下，内源性半胱天冬酶-10的死亡受体募集与凋亡启动。
J Biol Chem. 2001 Dec 7;276(49):46639-46. doi: 10.1074/jbc.M105102200. Epub 2001 Oct 2.
3
Apoptosis-regulating proteins as targets for drug discovery.作为药物研发靶点的细胞凋亡调节蛋白
Trends Mol Med. 2001 Jul;7(7):314-9. doi: 10.1016/s1471-4914(01)02026-3.
4
DNA methylation, methyltransferases, and cancer.DNA甲基化、甲基转移酶与癌症。
Oncogene. 2001 May 28;20(24):3139-55. doi: 10.1038/sj.onc.1204341.
5
Nucleotide substitution in the ectodomain of trail receptor DR4 is associated with lung cancer and head and neck cancer.
Clin Cancer Res. 2001 Jun;7(6):1688-97.
6
The Pezcoller lecture: cancer cell cycles revisited.佩兹科勒讲座：重探癌细胞周期
Cancer Res. 2000 Jul 15;60(14):3689-95.
7
Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5.Apo2L/TRAIL 依赖性地将内源性 FADD 和半胱天冬酶 -8 募集至死亡受体 4 和 5。
Immunity. 2000 Jun;12(6):611-20. doi: 10.1016/s1074-7613(00)80212-5.
8
Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN.在伴有MYCN扩增的儿童神经母细胞瘤中，半胱天冬酶8优先缺失或沉默。
Nat Med. 2000 May;6(5):529-35. doi: 10.1038/75007.
9
Differential retinoblastoma and p16(INK4A) protein expression in neuroendocrine tumors of the lung.肺神经内分泌肿瘤中视网膜母细胞瘤与p16(INK4A)蛋白的差异表达
Cancer. 2000 Feb 1;88(3):550-6.
10
Differences in expression of pro-caspases in small cell and non-small cell lung carcinoma.小细胞肺癌和非小细胞肺癌中前半胱天冬酶表达的差异。
Biochem Biophys Res Commun. 1999 Aug 27;262(2):381-7. doi: 10.1006/bbrc.1999.1191.

Is caspase-8 a neuroendocrine lung tumor suppressor?

作者信息

Mazumder Suparna, Almasan Alexandru

机构信息

Department of Cancer Biology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.

出版信息

Cancer Biol Ther. 2002 Jan-Feb;1(1):70-1. doi: 10.4161/cbt.1.1.46.

DOI:10.4161/cbt.1.1.46
PMID:12197486
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2519113/
Abstract
摘要