Cohen R D
University of Chicago Medical Center, Chicago, IL 60637, USA.
Aliment Pharmacol Ther. 2002 Sep;16(9):1603-9. doi: 10.1046/j.1365-2036.2002.01323.x.
Health-related quality of life studies provide insight into the influence of Crohn's disease on patients' lives, and the potential impact on professional and personal productivity.
To compare health-related quality of life in Crohn's disease patients with that in other patients and healthy controls, and between medically and surgically treated Crohn's disease patients, and to correlate health-related quality of life with Crohn's disease activity.
An expanded MEDLINE search of full length, English language, adult Crohn's disease studies from January 1966 to September 2000 was performed. The key words utilized were: 'Quality of Life', 'Health Status' or 'Health Related Quality of Life' and 'Crohn's' or 'Inflammatory Bowel Disease'.
A total of 258 articles were identified; 236 subsequently were excluded, leaving 22 for analysis. Compared with Crohn's disease patients, the health-related quality of life was better in healthy controls and in ulcerative colitis patients (except pre-colectomy), but similar to or worse than that in many other medical conditions. The health-related quality of life was directly correlated with Crohn's disease activity, and was worse in active disease than in remission. The health-related quality of life was improved only in the short term in surgically vs. medically treated Crohn's disease patients.
Health-related quality of life analysis provides important insights into the impact of Crohn's disease, and should be included in clinical trials. Researchers, clinicians and other health care providers need to be cognizant of the impact of the health-related quality of life upon patients' lives.
与健康相关的生活质量研究有助于深入了解克罗恩病对患者生活的影响，以及对职业和个人生产力的潜在影响。
比较克罗恩病患者与其他患者及健康对照者的健康相关生活质量，以及药物治疗和手术治疗的克罗恩病患者之间的健康相关生活质量，并将健康相关生活质量与克罗恩病活动度相关联。
对1966年1月至2000年9月期间发表的英文成人克罗恩病全长研究进行了扩展的MEDLINE检索。使用的关键词为：“生活质量”、“健康状况”或“与健康相关的生活质量”以及“克罗恩病”或“炎症性肠病”。
共识别出258篇文章；随后排除236篇，剩余22篇进行分析。与克罗恩病患者相比，健康对照者和溃疡性结肠炎患者（除结肠切除术前）的健康相关生活质量更好，但与许多其他疾病的患者相似或更差。健康相关生活质量与克罗恩病活动度直接相关，活动期疾病患者的健康相关生活质量比缓解期患者更差。与药物治疗的克罗恩病患者相比，手术治疗的患者仅在短期内健康相关生活质量有所改善。
健康相关生活质量分析为克罗恩病的影响提供了重要见解，应纳入临床试验。研究人员、临床医生和其他医疗保健提供者需要认识到健康相关生活质量对患者生活的影响。
