van Herwaarden M A, Samsom M, Rydholm H, Smout A J P M
Gastrointestinal Research Unit, Department of Gastroenterology, University Medical Center Utrecht, The Netherlands.
Aliment Pharmacol Ther. 2002 Sep;16(9):1655-62. doi: 10.1046/j.1365-2036.2002.01325.x.
Baclofen decreases gastro-oesophageal reflux episodes in healthy subjects by reducing the incidence of transient lower oesophageal sphincter relaxations.
To investigate the effect of baclofen on reflux symptoms, oesophageal pH and lower oesophageal sphincter manometry in patients with gastro-oesophageal reflux disease.
A double-blind, placebo-controlled, two-way crossover design was used to study the effect of baclofen on heartburn and regurgitation 3 h after a provocation test meal in 37 patients with gastro-oesophageal reflux disease. Additionally, in 20 of these patients, the effect of baclofen on oesophageal pH, transient lower oesophageal sphincter relaxations and basal lower oesophageal sphincter pressure was studied.
Baclofen significantly decreased the acid reflux time and the incidence of gastro-oesophageal reflux episodes (8.3 +/- 8.8% vs. 12.4 +/- 12.0%, P = 0.03 and 10.9 +/- 7.3 per 3 h vs. 18.7 +/- 12.4 per 3 h). The incidence of transient lower oesophageal sphincter relaxations was significantly lower with baclofen than with placebo (15.1 +/- 6.4 per 3 h vs. 22.8 +/- 5.4 per 3 h, P < 0.0001). Lower oesophageal sphincter pressure and the percentage of transient lower oesophageal sphincter relaxations associated with reflux were not affected by baclofen. No significant effect on symptom scores was observed.
Baclofen decreases post-prandial acid reflux in patients with gastro-oesophageal reflux disease by reducing the incidence of transient lower oesophageal sphincter relaxations. No effect of a single dose of baclofen on reflux symptoms could be demonstrated in this 3-h post-prandial study.
巴氯芬通过降低一过性下食管括约肌松弛的发生率，减少健康受试者的胃食管反流发作次数。
研究巴氯芬对胃食管反流病患者反流症状、食管pH值及下食管括约肌测压的影响。
采用双盲、安慰剂对照、双向交叉设计，研究巴氯芬对37例胃食管反流病患者在激发试验餐后3小时烧心和反流的影响。此外，对其中20例患者研究了巴氯芬对食管pH值、一过性下食管括约肌松弛及基础下食管括约肌压力的影响。
巴氯芬显著降低了酸反流时间和胃食管反流发作的发生率（8.3±8.8%对12.4±12.0%，P = 0.03；每3小时10.9±7.3次对每3小时18.7±12.4次）。巴氯芬组一过性下食管括约肌松弛的发生率显著低于安慰剂组（每3小时15.1±6.4次对每3小时22.8±5.4次，P < 0.0001）。巴氯芬对下食管括约肌压力及与反流相关的一过性下食管括约肌松弛百分比无影响。未观察到对症状评分有显著影响。
巴氯芬通过降低一过性下食管括约肌松弛的发生率，减少胃食管反流病患者餐后的酸反流。在这项餐后3小时的研究中，未证明单剂量巴氯芬对反流症状有影响。
