Antoniak H L, Babych N O, Solohub L I, Snityns'kyĭ V V
Lviv State Agrarian University.
Ukr Biokhim Zh (1999). 2002 Jan-Feb;74(1):5-18.
New data concerning molecular structure, localization and functions of iodothyronine deiodinases in animal and human organisms are reviewed in the article. Mechanisms of 5- and 5'-deiodination of thyroid hormones by intracellular iodothyronine deiodinases are considered, the role of these enzymes in the processes of biologically active iodothyronine formation and thyroid hormone inactivation are shown. The data which suggest functioning iodothyronine-5'-deiodinases in the cells of haemopoietic and lymphopoietic systems, and connection between the rate of enzyme expression and cell differentiation level are adduced. Participation of thyroid hormones and other factors in the regulation of expression and functional activities of iodothyronine-5'-deiodinases in the cells is discussed. The important role of iodothyronine deiodinases in mechanisms of optimization of intracellular thyroid status in altered physiological state of organism, during ontogenesis and in pathological conditions is considered.
本文综述了有关动物和人体中碘甲状腺原氨酸脱碘酶的分子结构、定位及功能的新数据。文中探讨了细胞内碘甲状腺原氨酸脱碘酶对甲状腺激素进行5-脱碘和5'-脱碘的机制，展示了这些酶在生物活性碘甲状腺原氨酸形成过程及甲状腺激素失活过程中的作用。文中还列举了提示碘甲状腺原氨酸-5'-脱碘酶在造血和淋巴细胞生成系统细胞中发挥作用以及酶表达速率与细胞分化水平之间联系的数据。讨论了甲状腺激素和其他因素参与细胞中碘甲状腺原氨酸-5'-脱碘酶表达及功能活性调控的情况。文中认为碘甲状腺原氨酸脱碘酶在机体生理状态改变、个体发育及病理状况下优化细胞内甲状腺状态的机制中具有重要作用。
