Sharifi-Rad Javad, Quispe Cristina, Castillo Carla Marina Salgado, Caroca Rodrigo, Lazo-Vélez Marco A, Antonyak Halyna, Polishchuk Alexandr, Lysiuk Roman, Oliinyk Petro, De Masi Luigi, Bontempo Paola, Martorell Miquel, Daştan Sevgi Durna, Rigano Daniela, Wink Michael, Cho William C
Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador.
Facultad de Ciencias de la Salud, Universidad Arturo Prat, Avda. Arturo Prat 2120, Iquique 1110939, Chile.
Oxid Med Cell Longev. 2022 Feb 21;2022:3848084. doi: 10.1155/2022/3848084. eCollection 2022.
Ellagic acid (EA) is a bioactive polyphenolic compound naturally occurring as secondary metabolite in many plant taxa. EA content is considerable in pomegranate ( L.) and in wood and bark of some tree species. Structurally, EA is a dilactone of hexahydroxydiphenic acid (HHDP), a dimeric gallic acid derivative, produced mainly by hydrolysis of ellagitannins, a widely distributed group of secondary metabolites. EA is attracting attention due to its antioxidant, anti-inflammatory, antimutagenic, and antiproliferative properties. EA displayed pharmacological effects in various and model systems. Furthermore, EA has also been well documented for its antiallergic, antiatherosclerotic, cardioprotective, hepatoprotective, nephroprotective, and neuroprotective properties. This review reports on the health-promoting effects of EA, along with possible mechanisms of its action in maintaining the health status, by summarizing the literature related to the therapeutic potential of this polyphenolic in the treatment of several human diseases.
鞣花酸（EA）是一种具有生物活性的多酚类化合物，作为次生代谢产物天然存在于许多植物类群中。石榴（L.）以及一些树种的木材和树皮中鞣花酸含量可观。从结构上看，鞣花酸是六羟基联苯二酸（HHDP）的双内酯，六羟基联苯二酸是一种二聚体没食子酸衍生物，主要由鞣花单宁水解产生，鞣花单宁是一类广泛分布的次生代谢产物。鞣花酸因其抗氧化、抗炎、抗诱变和抗增殖特性而备受关注。鞣花酸在各种体外和体内模型系统中均表现出药理作用。此外，鞣花酸的抗过敏、抗动脉粥样硬化、心脏保护、肝脏保护、肾脏保护和神经保护特性也有充分的文献记载。本综述通过总结与这种多酚在治疗几种人类疾病中的治疗潜力相关的文献，报道了鞣花酸对健康的促进作用及其维持健康状态的可能作用机制。
