Durelli L, Delsedime M, Mazzarino M, Mutani R
Riv Neurol. 1975 Oct-Dec;45(4):391-8.
To test taurine preventive antiepileptic effect a 90-minute taurine cortical perfusion was made to 8 cats in the left sensory-motor area. A cobalt lesion was then made in the same area following routine. In all cats the beginning and subsequent development of the interictal and ictal epileptic picture were remarkably delayed in comparison with a control group of animals without taurine pretreatment. The taurine preventive action, as the consequence of its brain uptake, is discussed in comparison with the lack of taurine preventive action, when administered intraperitoneally (MUTANI et al., in press). The possibility of the taurine uptake by the normal brain and, therefore, of the prevention of the epilepsy would be related to the different anatomo-physiologic features of the barriers met in the two routes of administration.
为测试牛磺酸的预防性抗癫痫作用，对8只猫的左侧感觉运动区进行了90分钟的牛磺酸皮质灌注。随后按照常规方法在同一区域制造钴损伤。与未进行牛磺酸预处理的对照组动物相比，所有猫的发作间期和发作期癫痫症状的起始及后续发展均显著延迟。将牛磺酸因脑摄取而产生的预防性作用，与腹腔注射时牛磺酸缺乏预防性作用的情况（穆塔尼等人，即将发表）进行了讨论。正常脑摄取牛磺酸进而预防癫痫的可能性，可能与两种给药途径中遇到的屏障不同的解剖生理特征有关。
