Engelhard Victor H, Brickner Anthony G, Zarling Angela L
Carter Immunology Center and Department of Microbiology, School of Medicine, University of Virginia, P.O. Box 801386, Charlottesville, VA 22908, USA.
Mol Immunol. 2002 Oct;39(3-4):127-37. doi: 10.1016/s0161-5890(02)00096-2.
MHC class I molecules are responsible for the presentation of antigenic peptides to CD8+ T lymphocytes. Based on their relatively promiscuous binding of peptides, these molecules display information derived from a large fraction of proteins that are made inside the cell. This review describes our characterization of the peptides comprising this repertoire, with particular attention given to their complexity and quantities, their post-translational modification, and the pathways leading to their expression.
MHC I类分子负责将抗原肽呈递给CD8+ T淋巴细胞。基于它们对肽的相对宽泛的结合，这些分子展示了来自细胞内大量蛋白质的信息。本综述描述了我们对构成该库的肽的表征，特别关注它们的复杂性和数量、它们的翻译后修饰以及导致它们表达的途径。
