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葡萄球菌疫苗

Staphylococcal vaccines.

作者信息

Michie Colin A

机构信息

Ealing Hospital NHS Trust, Uxbridge Road, London, UK UB1 3HW.

出版信息

Trends Immunol. 2002 Sep;23(9):461-3. doi: 10.1016/s1471-4906(02)02270-6.

DOI:10.1016/s1471-4906(02)02270-6
PMID:12200069
Abstract

Vaccination has proved relatively unsuccessful against the common mammalian commensal bacteria Staphylococcus, despite almost a century of experimentation. Recent progress in clinical trials, animal models and molecular laboratories offers hope that these organisms might be partially or wholly controlled by augmenting host responses.

摘要

尽管经过了近一个世纪的试验,但事实证明,接种疫苗对常见的哺乳动物共生细菌葡萄球菌的预防效果相对不佳。临床试验、动物模型和分子实验室的最新进展带来了希望,即通过增强宿主反应,这些微生物可能会得到部分或完全控制。

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A mutant of staphylococcal enterotoxin C devoid of bacterial superantigenic activity elicits a Th2 immune response for protection against Staphylococcus aureus infection.一种缺乏细菌超抗原活性的葡萄球菌肠毒素C突变体引发Th2免疫反应以抵御金黄色葡萄球菌感染。
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