Ganderton D, Lewis D, Davies R, Meakin B, Brambilla G, Church T
Vectura Ltd., Bath, U.K.
Respir Med. 2002 Aug;96 Suppl D:S3-8. doi: 10.1016/s0954-6111(02)80018-x.
Although popular, the pressurized metered dose inhaler generates coarse, fast moving clouds so that the fraction reaching the lung is small. These shortcomings can be redressed by Modulite which permutes the following variables: the non-volatile components of a solution formula, the actuator orifice geometry, the volume of the metered solution and the vapour pressure of the propellants. This permits the design of aerosols with chosen particle size and plume speed. This facilitates co-ordination of dose generation with inspiration, reduces oropharyngeal deposition and provides a mechanism for targeting drug delivery to different parts of the lung. These principles are exemplified by designing an HFA-propelled beclometasone dipropionate product which closely matches existing products which use chlorofluorocarbons.
尽管压力定量吸入器很受欢迎，但它会产生粗大、快速移动的药雾，因此到达肺部的比例很小。Modulite可以弥补这些缺点，它可以改变以下变量：溶液配方中的非挥发性成分、雾化器孔口几何形状、定量溶液的体积和推进剂的蒸气压。这使得能够设计出具有选定粒径和药雾速度的气雾剂。这有助于使剂量产生与吸气相协调，减少口咽沉积，并提供一种将药物输送到肺部不同部位的机制。通过设计一种以氢氟烷烃为推进剂的丙酸倍氯米松产品来举例说明这些原理，该产品与现有的使用氯氟烃的产品非常匹配。
