阿尔巴尼亚对膜翅目毒液过敏患者的特异性免疫疗法

Specific immunotherapy in Albanian patients with anaphylaxis to hymenoptera venoms.

作者信息

Mingomataj Ervin, Priftanji Alfred, Qirko Etleva, Dinh Q Thai, Fischer Axel, Peiser Christian, Groneberg David A

机构信息

Dept. of Allergy, Mother Theresa School of Medicine, University of Tirana, Tirana, Albania.

出版信息

BMC Dermatol. 2002 Aug 30;2:11. doi: 10.1186/1471-5945-2-11.

DOI:10.1186/1471-5945-2-11

PMID:12201901

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC128821/

Abstract

BACKGROUND

Severe allergic reactions during rush-specific immunotherapy (Rush-SIT) may occur in the treatment of hymenoptera sting allergy. The objective of the present study was to examine the characteristics of allergic reactions during Rush-SIT in a cohort of patients with allergy towards hymenoptera venom in the mediterranean population of Albania.

METHODS

A retrospective study was performed using the clinical reports of 37 patients with venom of bee (apinae), wasp (vespidae, subfamily vespinae) or paperwasp (vespidae, subfamily polistinae) allergy treated with Rush-SIT between 1987 and 1996. After hymenoptera sting allergy diagnosis according to anamnesis and intracutaneous tests the patient were treated with Rush-SIT. The protocol lasted 3 - 4 d with an increase in the concentration from 0.01 microg/ml to 100 microg/ml. Anaphylactic reactions were classified according to the Mueller-classification.

RESULTS

The frequency of reactions during Rush-SIT for bee-venom was 4.7% and for wasp-venom was 1.5% (p < 0.01). The mean frequency of reactions of Mueller grade II for the bee-venom Rush-SIT patients during the first 4 d (= 26 injections) was 0.73 and for the wasp-venom Rush-SIT patients 0.15. No patient experienced a third-degree reaction. 94.6% of the patient supported an end dose of 100 microg.

CONCLUSIONS

Rush-SIT is a reliable method for the treatment of anaphylactic reactions to hymenoptera venom even in less developed countries. Bee-venom Rush-SIT was found to cause higher numbers allergic reactions than wasp or paperwasp Rush-SIT.

摘要

背景

在蜂类特异性免疫疗法（快速免疫疗法，Rush-SIT）治疗膜翅目昆虫叮咬过敏时可能会发生严重过敏反应。本研究的目的是调查阿尔巴尼亚地中海人群中一组对膜翅目毒液过敏患者在快速免疫疗法期间过敏反应的特征。

方法

采用回顾性研究，使用1987年至1996年间接受快速免疫疗法治疗的37例对蜜蜂（蜜蜂亚科）、黄蜂（胡蜂科，胡蜂亚科）或马蜂（胡蜂科，马蜂亚科）毒液过敏患者的临床报告。根据病史和皮内试验诊断膜翅目昆虫叮咬过敏后，患者接受快速免疫疗法治疗。方案持续3 - 4天，浓度从0.01微克/毫升增加到100微克/毫升。过敏反应根据米勒分类法进行分类。