Kleinrok Z, Jagiello-Wójtowicz E, Sieklucka M
Arch Immunol Ther Exp (Warsz). 1975;23(6):769-76.
Fluorostigmine (DFP) injected i.p. in doses of 2-45 and 5-0 mg/kg in mice distinctly lowered levels of noradrenaline in the brain, raised levels of dopamine slightly, and very distinctly raised levels of 5-hydroxytryptamine and 5-hydroxyindoleacetic acid. The same dose also weakened MAO activity and diminished oxygen uptake by brain tissue. Drugs which antagonized the above-mentioned changes in the levels of biogenic amine (L-DOPA, PCPA, reserpine) or blocked receptors (phentolamine) only slightly diminished acute toxicity of DFP. On the other hand, a-methyl-p-tyrosine, d,l-tryptophane and nialamide had virtually no effect on acute toxicity.
腹腔注射剂量为2 - 45毫克/千克和5 - 0毫克/千克的氟膦斯的明（DFP）可显著降低小鼠脑中去甲肾上腺素的水平，使多巴胺水平略有升高，并非常显著地提高5 - 羟色胺和5 - 羟吲哚乙酸的水平。相同剂量还会减弱单胺氧化酶（MAO）的活性并减少脑组织的氧摄取。拮抗上述生物胺水平变化的药物（左旋多巴、对氯苯丙氨酸、利血平）或阻断受体的药物（酚妥拉明）只能略微降低DFP的急性毒性。另一方面，α-甲基对酪氨酸、消旋色氨酸和尼亚酰胺对急性毒性几乎没有影响。
