Effects of fluorostigmine, toxogonin and atropine on monoamine oxidase activity and the level of biogenic amines in mouse brain.

Effects of fluorostigmine, toxogonin and atropine on monoamine oxidase activity and the level of biogenic amines in mouse brain. Acta physiol. pol., 1979, 30 (4): 437--444. Fluorostigmine (DFP) given i.p. to mice in doses of 1.2 and 2.45 mg/kg reduced MAO activity in the brain. Given in doses of 0.6 and 1.2 mg/kg it reduced the level of noradrenaline and dopamine as well as 5-hydroxytryptamine in the brain. DFP in such doses had no effect on the brain level of 5-hydroxyindoloacetic acid. Toxogonin (5 mg/kg i.p.) or atropine (5 mg/kg i.p.) given together with DFP reduced or abolished completely the inhibitory effect of DFP.