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2-羧基色满酮-4的新型衍生物作为潜在的抗炎药物。I. 顺式和反式-β-2,4-二羟基苯甲酰丙烯酸及其衍生物。

New derivatives of 2-carboxychromanone-4 as potential antiinflammatory drugs. I. Cis-and trans-beta-2,4-dihydroxybenzoylacrylic acids and their derivatives.

作者信息

Konieczny M, Korngut S

出版信息

Arch Immunol Ther Exp (Warsz). 1975;23(6):809-15.

PMID:1220632
Abstract

Proof is presented that the product of the reaction of resorcin and maleic anhydride in the presence of aluminum chloride in ethylene chloride solutions is cis-beta-2,4-dihydroxybenzoylacrylic acid (I). Cis and trans acids (I and II) were isomerized to 2-carboxy-7-hydroxychromanone-4(III). Reactions of acetylation of compounds I, II and III were studied.

摘要

有证据表明，间苯二酚与马来酸酐在氯化铝存在下于二氯乙烷溶液中的反应产物是顺式-β-2,4-二羟基苯甲酰基丙烯酸（I）。顺式和反式酸（I和II）异构化为2-羧基-7-羟基色满酮-4（III）。研究了化合物I、II和III的乙酰化反应。

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