Sladowska H
Farmaco Sci. 1979 Nov;34(11):979-86.
The synthesis and the structure of some aminomethyl derivatives of 1-cyclohexylbarbituric acids, obtained by the Mannich reaction, are described. Acids, containing a pyrrolidinomethyl group in the position 5 were found to have the barbituric ring in the enolic form, stabilized by a hydrogen bond with the pyrrolidine nitrogen atom. Some of the described compounds displayed antiinflammatory activity.
描述了通过曼尼希反应得到的一些1-环己基巴比妥酸的氨甲基衍生物的合成及其结构。发现5位含有吡咯烷基甲基的酸具有烯醇式的巴比妥环，该环通过与吡咯烷氮原子形成氢键而得以稳定。所描述的一些化合物具有抗炎活性。
