Melnik B, Hariry H, Vakilzadeh F, Gropp C, Sitzer G
Dermatologie, Umweltmedizin und Gesundheitstheorie, Universität Osnabrück, Germany.
Hautarzt. 2002 Sep;53(9):618-21. doi: 10.1007/s00105-002-0347-7.
A 45 year old female patient presented with the cutaneous manifestations of malignant atrophic papulosis (Köhlmeier-Degos disease) for two years. The typical papules with central porcelain-white atrophy correspond histologically to wedge-shaped necrosis of the connective tissue due to thrombotic occlusion of small vessels in the corium. The pathogenesis of malignant atrophic papulosis and effective treatment modalities are unknown. A slow virus infection has been suggested by some authors. Therefore, we attempted an immune therapy with interferon alpha-2a over a period of 11 months, but failed to cause a significant effect on the appearance and progression of the skin lesions. Furthermore, we could not confirm the effectiveness of a recently reported treatment modality with pentoxifylline and aspirin administered to our patient over a period of 5 months.
一名45岁女性患者出现恶性萎缩性丘疹病（科尔迈尔-德戈斯病）的皮肤表现已有两年。典型的中央呈瓷白色萎缩的丘疹在组织学上对应于真皮中小血管血栓闭塞导致的结缔组织楔形坏死。恶性萎缩性丘疹病的发病机制和有效治疗方式尚不清楚。一些作者提出可能是慢病毒感染。因此，我们尝试用α-2a干扰素进行了11个月的免疫治疗，但对皮肤损害的外观和进展未产生显著影响。此外，我们也未能证实最近报道的己酮可可碱和阿司匹林联合治疗方式对我们的患者在5个月治疗期内的有效性。
