Lindpaintner Klaus
Roche Genetics, F. Hoffmann-La Roche Ltd, Basel, Switzerland.
Br J Clin Pharmacol. 2002 Aug;54(2):221-30. doi: 10.1046/j.1365-2125.2002.01630.x.
Pharmacogenetic approaches are widely expected to bring about a "revolution" in medicine. While the application of molecular genetic approaches to disease research will provide us with new opportunities for progressively more targeted and, hopefully, more effective treatments, these developments will be evolutionary in nature and will, for their realization, still require the painstaking process that discovering and developing a new drug entails. It is also quintessential for the realization of these promises that we support a more rational understanding and more realistic expectations in the public at large through dialogue and information.
药物遗传学方法被广泛认为将给医学带来一场“革命”。虽然将分子遗传学方法应用于疾病研究将为我们提供新的机会,以实现更具针对性、有望更有效的治疗,但这些进展本质上是渐进式的,而且要实现这些进展,仍需要经历发现和开发一种新药所必需的艰苦过程。同样至关重要的是,为了实现这些承诺,我们要通过对话和信息传播,促使广大公众形成更理性的认识和更现实的期望。