哮喘药物基因组学

Asthma pharmacogenomics.

作者信息

Hawkins Gregory A, Weiss Scott T, Bleecker Eugene R

机构信息

Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA.

出版信息

Immunol Allergy Clin North Am. 2005 Nov;25(4):723-42. doi: 10.1016/j.iac.2005.09.004.

DOI:10.1016/j.iac.2005.09.004

PMID:16257635

Abstract

It is expected that future treatments will be preceded by genetic tests to prescribe the most effect asthma medication while lowering the risk of adverse side effects. However, it will not be necessary to describe all the genetic determinants affecting drug response to apply pharmacogenomics to asthma therapy. Whether pharmacogenomics becomes common practice may not depend on the availability of tests, but on factors such as affordability, ease of application, and ease of interpreting the results.

摘要

预计未来的治疗将先进行基因检测，以便开出最有效的哮喘药物，同时降低不良反应的风险。然而，在将药物基因组学应用于哮喘治疗时，并不需要描述所有影响药物反应的基因决定因素。药物基因组学是否成为常规做法可能不取决于检测的可用性，而是取决于可负担性、应用的简便性和结果解释的难易程度等因素。