Tebano Maria Teresa, Domenici Maria Rosaria, Popoli Patrizia
Department of Pharmacology, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.
Eur J Pharmacol. 2002 Aug 30;450(3):253-7. doi: 10.1016/s0014-2999(02)02148-9.
The influence of the adenosine A(2A) receptor antagonist SCH 58261 (7-(2-phenylethyl)-5-amino-2-(2-furyl)-pyrazolo-[4,3-e]-1,2,4-trizolo[1,5-c] pyrimidine) (50, 200 nM, 1 microM) on quinolinic acid effects has been studied in rat striatal and hippocampal slices. Quinolinic acid induced disappearance of field potentials at concentrations of 500 microM and 2 mM in hippocampal and corticostriatal slices, respectively. We found that 1 microM SCH 58261 prevented quinolinic acid-induced field potential disappearance in corticostriatal but not in hippocampal slices. This finding demonstrates that the peculiar binding profile of SCH 58261 and the predominance in the hippocampus of "atypical" adenosine A(2A) receptor population (not recognized by SCH 58261) could have a functional relevance in the occurrence of region-specific neuroprotective effects.
在大鼠纹状体和海马切片中，研究了腺苷A(2A)受体拮抗剂SCH 58261（7-(2-苯乙基)-5-氨基-2-(2-呋喃基)-吡唑并-[4,3-e]-1,2,4-三唑并[1,5-c]嘧啶）（50、200 nM、1 microM）对喹啉酸作用的影响。喹啉酸分别在海马切片和皮质纹状体切片中浓度为500 microM和2 mM时诱导场电位消失。我们发现，1 microM的SCH 58261可防止喹啉酸诱导皮质纹状体切片中场电位消失，但不能防止海马切片中的场电位消失。这一发现表明，SCH 58261独特的结合特性以及海马中“非典型”腺苷A(2A)受体群体（不被SCH 58261识别）的优势可能与区域特异性神经保护作用的发生具有功能相关性。
