Pinheiro Bruno Gonçalves, Luz Diandra Araújo, Cartágenes Sabrina de Carvalho, Fernandes Luanna de Melo Pereira, Farias Sarah Viana, Kobayashi Natália Harumi Correa, Fontes-Júnior Enéas Andrade, Ferreira Samira G, Cunha Rodrigo A, Prediger Rui Daniel, Maia Cristiane do Socorro Ferraz
Neurosciences and Cellular Biology Post Graduation Program, Biological Sciences Institute, Federal University of Pará, Belém 66075-110, PA, Brazil.
Behavioral and Inflammatory Pharmacology Laboratory, Health Sciences Institute, Pharmacy College, Federal University of Pará, Belém 66075-110, PA, Brazil.
Pharmaceuticals (Basel). 2022 Oct 26;15(11):1323. doi: 10.3390/ph15111323.
Binge drinking intake is the most common pattern of ethanol consumption by adolescents, which elicits emotional disturbances, mainly anxiety and depressive symptoms, as well as cognitive alterations. Ethanol exposure may act on the adenosine neuromodulation system by increasing adenosine levels, consequently increasing the activation of adenosine receptors in the brain. The adenosine modulation system is involved in the control of mood and memory behavior. However, there is a gap in the knowledge about the exact mechanisms related to ethanol exposure's hazardous effects on the immature brain (i.e., during adolescence) and the role of the adenosine system thereupon. The present review attempts to provide a comprehensive picture of the role of the adenosinergic system on emotional and cognitive disturbances induced by ethanol during adolescence, exploring the potential benefits of caffeine administration in view of its action as a non-selective antagonist of adenosine receptors.
暴饮是青少年最常见的乙醇消费模式，会引发情绪障碍，主要是焦虑和抑郁症状，以及认知改变。乙醇暴露可能通过提高腺苷水平作用于腺苷神经调节系统，从而增加大脑中腺苷受体的激活。腺苷调节系统参与情绪和记忆行为的控制。然而，关于乙醇暴露对未成熟大脑（即青春期）产生有害影响的确切机制以及腺苷系统在其中的作用，目前仍存在知识空白。本综述试图全面阐述腺苷能系统在青春期乙醇诱导的情绪和认知障碍中的作用，并鉴于咖啡因作为腺苷受体的非选择性拮抗剂的作用，探讨其给药的潜在益处。
