Porreca Ettore, Di Febbo Concetta, di Castelnuovo Augusto, Baccante Giovanna, Amore Concetta, Angelini Antonio, Di Nisio Marcello, Donati Maria, Cuccurullo Franco, Iacoviello Licia
Dipartimento di Medicina e Scienze dell'Invecchiamento, Università di Chieti, Facoltà di Medicina e Chirurgia, Centro Servizi Biomedici, Via dei Vestini, 66013, Chieti, Italy.
Atherosclerosis. 2002 Nov;165(1):159-66. doi: 10.1016/s0021-9150(02)00199-5.
Inflammatory markers have been demonstrated to be associated with increased risk of cardiovascular events. In this setting, C-reactive protein (CRP) was shown to add predictive value to cholesterol levels. We investigated hypercholesterolemic patients and related their inflammatory variables and their coagulation state focusing on factor VII, a coagulation protein which plays an established role in thrombogenesis. We examined the relationship between factor VII clotting activity (FVIIc), FVII antigen (FVIIAg) and activated FVII (FVIIa) levels against CRP, interleukin-6 soluble receptor (IL-6sR), P-selectin, soluble intercellular adhesion molecule-1 (ICAM-1) and transforming growth factor-beta(1) (TGF-beta(1)), in fifty-eight hypercholesterolemic subjects. Patients were subjected to 6-8 weeks of lipid lowering treatment with diet or diet plus pravastatin (40 mg/day). Univariate analysis showed that FVII levels were positively associated with CRP (FVIIAg: r=0.56, P<0.0001; FVIIc: r=0.57, P<0.0001; FVIIa: r=0.39, P<0.001) and IL-6sR (FVIIAg: r=0.59, P<0.0001; FVIIc: r=0.52, P<0.0001; FVIIa: r=0.47; P<0.001). CRP was still correlated, at the baseline, with FVIIAg and FVIIc levels after multiple stepwise regression analysis (FVIIAg: P<0.0001; FVIIc: P<0.0001, respectively) and with FVIIAg at the end of lipid lowering treatment (P<0.0001). Our data indicate that the FVII level is independently associated with inflammatory variables and suggest their pathophysiological link in hypercholesterolemic patients.
炎症标志物已被证明与心血管事件风险增加有关。在此背景下，C反应蛋白（CRP）被证明能增加胆固醇水平的预测价值。我们对高胆固醇血症患者进行了研究，重点关注凝血因子VII（一种在血栓形成中起既定作用的凝血蛋白），分析了他们的炎症变量和凝血状态。我们检测了58名高胆固醇血症患者的凝血因子VII凝血活性（FVIIc）、FVII抗原（FVIIAg）和活化FVII（FVIIa）水平与CRP、白细胞介素-6可溶性受体（IL-6sR）、P-选择素、可溶性细胞间黏附分子-1（ICAM-1）和转化生长因子-β(1)（TGF-β(1)）之间的关系。患者接受了为期6-8周的饮食或饮食加普伐他汀（40毫克/天）的降脂治疗。单因素分析显示，FVII水平与CRP（FVIIAg：r = 0.56，P < 0.0001；FVIIc：r = 0.57，P < 0.0001；FVIIa：r = 0.39，P < 0.001）和IL-6sR（FVIIAg：r = 0.59，P < 0.0001；FVIIc：r = 0.52，P < 0.0001；FVIIa：r = 0.47；P < 0.001）呈正相关。经过多重逐步回归分析，基线时CRP仍与FVIIAg和FVIIc水平相关（FVIIAg：P < 0.0001；FVIIc：P < 0.0001），降脂治疗结束时与FVIIAg相关（P < 0.0001）。我们的数据表明，FVII水平与炎症变量独立相关，并提示它们在高胆固醇血症患者中的病理生理联系。
