Kario K, Matsuo T, Nakao K
Department of Internal Medicine, Hyogo Prefectural Awaji Hospital, Japan.
Thromb Haemost. 1991 Jan 23;65(1):25-7.
To investigate the age-related increase in coagulation factor VII (FVII) and its significance in the elderly, we measured FVII coagulation activity (FVIIc), FVII antigen (FVIIag), and D-dimer levels in 150 normal subjects ranging in age from 60 to 98 years. We also measured blood lipid fractions and serum cholinesterase activity (ChE), as an indicator of hepatic protein synthesis. FVIIc (141 +/- 36%), FVIIag (136 +/- 28%), and D-dimer (0.150 +/- 0.372 microgram/ml) levels were significantly higher in the elderly than in younger controls (p less than 0.01). Both FVIIc and FVIIag levels were significantly higher in elderly women than in elderly men (p less than 0.01). FVIIc levels significantly correlated with FVIIag levels, but not with D-dimer levels. FVIIag was more closely correlated with ChE levels in both sexes (men: r = 0.425, women: r = 0.365, p less than 0.001) than with the lipid fractions. When the elderly subjects were divided into atherosclerotic and non-atherosclerotic groups, both FVIIc (p less than 0.01) and FVIIag (p less than 0.05) levels were higher in the former group. Moreover, the FVIIc/FVIIag ratio and ChE levels were higher in both the elderly men and women with atherosclerosis. These results suggest that in elderly subjects, especially with atherosclerosis, hepatic FVII synthesis and the activation of FVII zymogen are both accelerated.
为研究凝血因子VII（FVII）随年龄增长的变化及其在老年人中的意义，我们测定了150名年龄在60至98岁的正常受试者的FVII凝血活性（FVIIc）、FVII抗原（FVIIag）和D - 二聚体水平。我们还测定了血脂成分和血清胆碱酯酶活性（ChE），作为肝脏蛋白质合成的指标。老年人的FVIIc（141±36%）、FVIIag（136±28%）和D - 二聚体（0.150±0.372微克/毫升）水平显著高于年轻对照组（p<0.01）。老年女性的FVIIc和FVIIag水平均显著高于老年男性（p<0.01）。FVIIc水平与FVIIag水平显著相关，但与D - 二聚体水平无关。FVIIag在两性中与ChE水平的相关性（男性：r = 0.425，女性：r = 0.365，p<0.001）比与血脂成分的相关性更密切。当将老年受试者分为动脉粥样硬化组和非动脉粥样硬化组时，前一组的FVIIc（p<0.01）和FVIIag（p<0.05）水平均较高。此外，患有动脉粥样硬化的老年男性和女性的FVIIc/FVIIag比值和ChE水平均较高。这些结果表明，在老年受试者中，尤其是患有动脉粥样硬化的受试者，肝脏FVII合成和FVII酶原的激活均加速。
