Bowler Russell P, Crapo James D
National Jewish Medical and Research Center, Denver, CO 80236, USA.
J Allergy Clin Immunol. 2002 Sep;110(3):349-56. doi: 10.1067/mai.2002.126780.
There is ample evidence that allergic disorders, such as asthma, rhinitis, and atopic dermatitis, are mediated by oxidative stress. Excessive exposure to reactive oxygen and nitrogen species is the hallmark of oxidative stress and leads to damage of proteins, lipids, and DNA. Oxidative stress occurs not only as a result of inflammation but also from environmental exposure to air pollution and cigarette smoke. The specific localization of antioxidant enzymes in the lung and the rapid reaction of nitric oxide with reactive oxygen species, such as superoxide, suggest that antioxidant enzymes might also function as cell-signaling agents or regulators of cell signaling. Therapeutic interventions that decrease exposure to environmental reactive oxygen species or augment endogenous antioxidant defenses might be beneficial as adjunctive therapies for allergic respiratory disorders.
有充分证据表明，过敏性疾病，如哮喘、鼻炎和特应性皮炎，是由氧化应激介导的。过度暴露于活性氧和氮物种是氧化应激的标志，并导致蛋白质、脂质和DNA的损伤。氧化应激不仅是炎症的结果，也是环境暴露于空气污染和香烟烟雾的结果。抗氧化酶在肺中的特定定位以及一氧化氮与活性氧物种（如超氧化物）的快速反应表明，抗氧化酶也可能作为细胞信号传导剂或细胞信号调节剂发挥作用。减少环境活性氧暴露或增强内源性抗氧化防御的治疗干预措施可能作为过敏性呼吸道疾病的辅助治疗有益。
