七跨膜受体
Seven-transmembrane receptors.
作者信息
Pierce Kristen L, Premont Richard T, Lefkowitz Robert J
机构信息
The Howard Hughes Medical Institute and the Department of Medicine, Box 3821, Duke University Medical Center, Durham, North Carolina 27710, USA.
出版信息
Nat Rev Mol Cell Biol. 2002 Sep;3(9):639-50. doi: 10.1038/nrm908.
DOI:10.1038/nrm908
PMID:12209124
Abstract
Seven-transmembrane receptors, which constitute the largest, most ubiquitous and most versatile family of membrane receptors, are also the most common target of therapeutic drugs. Recent findings indicate that the classical models of G-protein coupling and activation of second-messenger-generating enzymes do not fully explain their remarkably diverse biological actions.
摘要
七跨膜受体是膜受体中最大、分布最广泛且功能最多样化的家族，也是治疗药物最常见的靶点。最近的研究结果表明，G蛋白偶联和第二信使生成酶激活的经典模型并不能完全解释它们极为多样的生物学作用。
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