Chatzopoulou Eirini, Fanourakis Galinos, Papanikolaou Nikolaos, Chatzistamou Ioulia, Dereka Xanthippi, Vastardis Heleni
U.F.R. d'Odontologie, Université Paris Cité, 1 Rue Maurice Arnoux, Montrouge, Paris, 92120, France.
Service of Odontology, Periodontal and Oral Surgery Unit, Rothschild Hospital (AP-HP), 5 Rue Santerre, Paris, 75012, France.
BMC Res Notes. 2025 Aug 22;18(1):370. doi: 10.1186/s13104-025-07443-5.
G protein-coupled receptor 126 (GPR126) gene has been implicated as a potential susceptibility factor for aggressive periodontitis in Japanese patients. This study aimed to investigate the presence of the GPR126 [c.3086 G > A] (rs536714306) polymorphism in patients with periodontitis in a Greek population and periodontal cases of European ancestry. A total of 82 subjects were recruited: 53 patients periodontally compromised (P) and 29 healthy controls (H). GPR126 genotyping was performed using Sanger sequencing. Additionally, data from the Gene-Lifestyle Interactions in Dental Endpoints (GLIDE) consortium were included in this study.
No variants (rs536714306) in the GPR126 gene were detected in any of the samples. The homozygous for the reference allele GG genotype was observed in 100% of participants across all groups examined. Absence of GPR126 [c.3086 G > A] polymorphism indicates no association with susceptibility to periodontitis in a Greek cohort and periodontally compromised cases of European ancestry. This is the first focused report evaluating the presence of this polymorphism in periodontitis patients in a European population. Further genome-wide studies in larger sample and diverse populations are warranted to fully elucidate the potential role of GPR126 polymorphisms in periodontal disease susceptibility.
G蛋白偶联受体126（GPR126）基因被认为是日本侵袭性牙周炎患者的潜在易感因素。本研究旨在调查希腊人群牙周炎患者及欧洲血统牙周病例中GPR126 [c.3086 G＞A]（rs536714306）多态性的存在情况。共招募了82名受试者：53名牙周受损患者（P）和29名健康对照者（H）。采用桑格测序法进行GPR126基因分型。此外，来自牙齿终点基因-生活方式相互作用（GLIDE）联盟的数据也纳入了本研究。
在任何样本中均未检测到GPR126基因的变异（rs536714306）。在所有检测组的100%参与者中均观察到参考等位基因GG基因型的纯合子。GPR126 [c.3086 G＞A]多态性的缺失表明在希腊队列和欧洲血统牙周受损病例中与牙周炎易感性无关。这是第一份评估欧洲人群牙周炎患者中这种多态性存在情况的重点报告。有必要在更大样本和不同人群中进行进一步的全基因组研究，以充分阐明GPR126多态性在牙周病易感性中的潜在作用。
