Field Tiffany, Diego Miguel, Hernandez-Reif Maria, Schanberg Saul, Kuhn Cynthia
Touch Research Institutes, University of Miami School of Medicine, Department of Pediatrics, Miami, FL 33101, USA.
Dev Psychobiol. 2002 Sep;41(2):147-55. doi: 10.1002/dev.10061.
Although infants have been noted to have greater relative right or left frontal EEG as early as the neonatal period, other ways in which these newborns differ have not been reported. In this study, 48 newborns were divided on the basis of greater relative right versus greater relative left frontal EEG to determine whether these groups differed in other ways at the neonatal period including behavior, physiology, and biochemistry. We also were interested in whether these EEG patterns were related to any prenatal maternal variables including mood states (depression, anxiety, anger) and biochemistry as well as fetal activity. The greater relative right frontal EEG newborns had mothers with lower prenatal and postnatal serotonin and higher postnatal cortisol levels. The mothers of the greater relative right frontal EEG newborns also had greater relative right frontal EEG activation and lower vagal tone. The greater relative right frontal EEG newborns themselves had elevated cortisol levels, showed a greater number of state changes during sleep/wake behavior observations, and performed less optimally on the Brazelton Neonatal Behavior Assessment (T. B. Brazelton, 1973) including the habituation, motor, range of state, excitability, and depressive symptoms scales. These data suggest that greater relative right frontal EEG newborns may be at greater risk for developmental problems than those with greater relative left frontal EEG activation. In addition, a discriminant function analysis correctly classified 67% of the newborns' EEGs by prenatal maternal variables, suggesting that these might be used to target pregnant women for prenatal intervention.
尽管早在新生儿期就已注意到婴儿的右侧或左侧额叶脑电图相对值较高，但尚未有关于这些新生儿在其他方面差异的报道。在本研究中，48名新生儿根据右侧额叶脑电图相对值较高与左侧额叶脑电图相对值较高进行分组，以确定这些组在新生儿期的其他方面是否存在差异，包括行为、生理和生物化学。我们还感兴趣的是，这些脑电图模式是否与任何产前母亲变量有关，包括情绪状态（抑郁、焦虑、愤怒）、生物化学以及胎儿活动。右侧额叶脑电图相对值较高的新生儿的母亲产前和产后血清素水平较低，产后皮质醇水平较高。右侧额叶脑电图相对值较高的新生儿的母亲右侧额叶脑电图激活程度也较高，迷走神经张力较低。右侧额叶脑电图相对值较高的新生儿自身皮质醇水平升高，在睡眠/觉醒行为观察期间状态变化次数较多，在布雷泽尔顿新生儿行为评估（T.B.布雷泽尔顿，1973年）中的表现较差，包括习惯化、运动、状态范围、兴奋性和抑郁症状量表。这些数据表明，右侧额叶脑电图相对值较高的新生儿可能比左侧额叶脑电图激活程度较高的新生儿面临更大的发育问题风险。此外，判别函数分析根据产前母亲变量正确分类了67%的新生儿脑电图，这表明这些变量可用于确定孕妇进行产前干预的目标。
