Iwaizumi Moriya, Yamada Masami, Kitagawa Mutsuo, Takehira Yasunori, Hanajima Kazunori, Murohisa Gou, Kawamura Motoko, Iwaoka Yasushi, Wada Tomohiko, Morita Satoru, Kawata Kazuhito
Department of Gastroenterology, Hamamatsu Medical Center.
Intern Med. 2002 Aug;41(8):629-32. doi: 10.2169/internalmedicine.41.629.
We present a rare occurrence of woman monozygotic twins with ulcerative colitis (UC). A 21-year-old woman came to our hospital because of diarrhea, abdominal pain and hematochezia. We diagnosed this case as proctitis type UC by endoscopic and histological findings. Six months later, her twin sister developed total colitis type UC. Both twins had HLA-A24, B52, DR2, and DQ1 serological types, and had DRB1*1502 DNA type, previously shown to be associated with UC. This case report suggested an association of genetic factor together with environmental factors in the etiology for UC.
我们报告了一例罕见的患有溃疡性结肠炎（UC）的女性单卵双胞胎病例。一名21岁女性因腹泻、腹痛和便血前来我院就诊。通过内镜和组织学检查结果，我们将该病例诊断为直肠炎型UC。六个月后，她的双胞胎姐姐患上了全结肠炎型UC。这对双胞胎均具有HLA-A24、B52、DR2和DQ1血清型，并且具有DRB1*1502 DNA型，先前研究表明该型与UC相关。本病例报告提示UC的病因中存在遗传因素与环境因素的关联。
