Wang L, Lu Y, Takashi T, Zhao M, Wu L, Zhou Z, Hiromasa N
Department of Oral Pathology, School of Stomatology, WCUMS, Chengdu 610041.
Hua Xi Yi Ke Da Xue Xue Bao. 1999 Sep;30(3):318-20, 323.
To study the characteristics of the mesenchymal cells of ameloblastic fibrosarcoma (AFS), three cases of AFS were studied immunohistochemically and ultrastructurally. The results showed that the mesenchymal component of AFS consisted predominantly of fibroblastic cells with a small number of undifferentiated cells, a few histiocytes and occasionally myofibroblastic cells under electron microscope. The fibroblastic cells were Vimentin positive only, and myofibroblastic cells were positive for Vimentin, HHF35 and alpha-SMA. The histiocytes were positive both for kp1 and PG-M1, suggesting that these cells were infiltrating cells from peripheral blood rather than histiocytic differentiation of tumor cells. Compared with ameloblastic fibroma, AFS showed much higher PCNA labeling index, suggesting higher proliferation activity of AFS.
为研究成釉细胞纤维肉瘤（AFS）间充质细胞的特征，对3例AFS进行了免疫组织化学和超微结构研究。结果显示，电镜下AFS的间充质成分主要由成纤维细胞组成，伴有少量未分化细胞、一些组织细胞，偶尔可见肌成纤维细胞。成纤维细胞仅波形蛋白阳性，肌成纤维细胞波形蛋白、HHF35和α-SMA阳性。组织细胞kp1和PG-M1均阳性，提示这些细胞是外周血浸润细胞，而非肿瘤细胞的组织细胞分化。与成釉细胞纤维瘤相比，AFS显示出更高的增殖细胞核抗原（PCNA）标记指数，提示AFS具有更高的增殖活性。
