大鼠的三叉神经上区向对侧的运动三叉神经核发送含有γ-氨基丁酸/甘氨酸的轴突终末。

The supratrigeminal region of the rat sends GABA/glycine-cocontaining axon terminals to the motor trigeminal nucleus on the contralateral side.

作者信息

Li Yun-Qing, Tao Fa-Sheng, Okamoto Keiko, Nomura Sakashi, Kaneko Takeshi, Mizuno Noboru

机构信息

Department of Anatomy and K.K. Leung Brain Research Center, The Fourth Military Medical University, Xi'an 710032, People's Republic of China.

出版信息

Neurosci Lett. 2002 Sep 13;330(1):13-6. doi: 10.1016/s0304-3940(02)00711-5.

DOI:10.1016/s0304-3940(02)00711-5

PMID:12213623

Abstract

The supratrigeminal region (STR), a reticular zone capping the motor trigeminal nucleus (Tm), contains gamma-aminobutyric acid (GABA)ergic and glycinergic neurons which send axons to the contralateral Tm (J. Comp. Neurol. 373 (1996) 498). In the present study we observed that some single synaptic terminals upon Tm motoneurons showed immunoreactivities (IRs) for both glutamic acid decarboxylase (GAD) and glycine transporter 2 (GlyT2). After injecting biotinylated dextran amine (BDA) into the STR, we further observed in the Tm contralateral to the BDA injection that some BDA-labeled axon terminals in close contact with Tm motoneurons showed both GAD- and GlyT2-IRs. Thus, the STR was indicated to send GABAergic/glycinergic axon terminals contralaterally to Tm motoneurons.

摘要

三叉神经上区（STR）是覆盖运动三叉神经核（Tm）的一个网状区域，包含γ-氨基丁酸（GABA）能和甘氨酸能神经元，这些神经元将轴突发送至对侧的Tm（《比较神经学杂志》373卷（1996年）498页）。在本研究中，我们观察到，一些位于Tm运动神经元上的单个突触终末对谷氨酸脱羧酶（GAD）和甘氨酸转运体2（GlyT2）均显示出免疫反应性（IRs）。在将生物素化葡聚糖胺（BDA）注入STR后，我们在与BDA注射部位对侧的Tm中进一步观察到，一些与Tm运动神经元紧密接触的BDA标记轴突终末同时显示出GAD和GlyT2免疫反应性。因此，表明STR向对侧的Tm运动神经元发送GABA能/甘氨酸能轴突终末。