Gogas J, Markopoulos C, Kouskos E, Gogas H, Mantas D, Antonopoulou Z, Kontzoglou K
2nd Department of Propedeutic Surgery, Athens University Medical School, Laiko General Hospital, Greece.
Eur J Gynaecol Oncol. 2002;23(4):333-4.
Granular cell tumor (GCT) is an uncommon, usually benign tumor that occasionally involves the breast. It is possibly of neural origin (Schwann cells) and usually occurs in premenopausal black women. Physical examination, mammographic, ultrasonographic findings and pathologic examination may suggest breast malignancy. Positive immunohistochemical staining of the cells for S-100 protein, NSE, and CEA is indicative of GCT. Surgical treatment of choice is wide local excision. We report a case of granular cell tumor of a female breast. A 52-yr-old white woman had a palpable mass close to her right axilla. Computer tomography (CT) showed a 3.74 cm mass in the mammary tail of Spencer. The findings were suspicious for malignancy and the lesion was widely resected. Pathologic examination showed granular cell tumor.
颗粒细胞瘤（GCT）是一种罕见的、通常为良性的肿瘤，偶尔会累及乳腺。它可能起源于神经（施万细胞），通常发生在绝经前的黑人女性中。体格检查、乳腺钼靶、超声检查结果及病理检查可能提示乳腺恶性肿瘤。细胞S-100蛋白、神经元特异性烯醇化酶（NSE）和癌胚抗原（CEA）免疫组化染色阳性提示颗粒细胞瘤。首选的手术治疗方法是广泛局部切除。我们报告一例女性乳腺颗粒细胞瘤病例。一名52岁白人女性右腋窝附近可触及肿块。计算机断层扫描（CT）显示斯宾塞乳腺尾部有一个3.74 cm的肿块。检查结果怀疑为恶性肿瘤，遂对病变进行广泛切除。病理检查显示为颗粒细胞瘤。
