通过[15O]水和正电子发射断层扫描（PET）测定正常受试者和惊恐障碍患者吸入二氧化碳后的全脑血流量。

Global cerebral blood flow after CO2 inhalation in normal subjects and patients with panic disorder determined with [15O]water and PET.

作者信息

Ponto Laura L Boles, Kathol Roger G, Kettelkamp Richard, Watkins G Leonard, Richmond John C W, Clark Jo, Hichwa Richard D

机构信息

Department of Radiology, PET Imaging Center, University of Iowa Hospitals and Clinics, Iowa City 52242, USA.

出版信息

J Anxiety Disord. 2002;16(3):247-58. doi: 10.1016/s0887-6185(02)00094-4.

DOI:10.1016/s0887-6185(02)00094-4

PMID:12214811

Abstract

OBJECTIVE

To determine the effect of CO2 inhalation on global cerebral blood flow (gCBF) and pCO2-adjusted gCBF in normal subjects and panic disorder patients.

METHOD

Global cerebral blood flow was determined using quantitative [15O] water imaging in normal subjects (n = 12) and panic disorder patients (n = 14) after inhalations of medical grade air and of 35%/65% CO2/O2 mixture, a known inducer of panic. The gCBF was calculated as an area-weighted mean value. The pCO2 -adjusted gCBF values were calculated based on the formula of Reiman et al. [Am. J. Psychiatr. 143 (1986) 469]. Data were analyzed using repeated-measures ANOVA and regression analyses.

RESULTS

The pCO2 values did not differ statistically between normals and panic patients. Panic patients exhibited a decrease in gCBF and stable pCO2-adjusted gCBF values in comparisons of AIR and CO2 inhalations, whereas normals exhibited stable gCBF and increasing pCO2-adjusted gCBF values.

CONCLUSIONS

Patients with panic disorder, especially when symptomatic, exhibited an abnormal pattern in gCBF response to provocation.

摘要

目的

确定吸入二氧化碳对正常受试者和惊恐障碍患者的全脑血流量（gCBF）以及经二氧化碳分压（pCO2）调整后的gCBF的影响。

方法

在正常受试者（n = 12）和惊恐障碍患者（n = 14）吸入医用级空气以及35%/65%二氧化碳/氧气混合物（一种已知的惊恐诱发剂）后，使用定量[15O]水成像技术测定全脑血流量。gCBF计算为面积加权平均值。经pCO2调整后的gCBF值根据雷曼等人的公式计算[《美国精神病学杂志》143（1986）469]。数据采用重复测量方差分析和回归分析进行分析。