Sergeeva T I, Iastrebov V V
Zh Mikrobiol Epidemiol Immunobiol. 1975 Nov(11):106-9.
The use of antitetanus serum (ATS) in the north taiga soil-vegetative zone and farther to the north is inexpedient because of an insignificant contamination of soil with B. tetani and a trivial contact of the population with soil. In the Arkhangelsk region with a high incidence of trauma and a low tetanus morbidity the damage caused to the population by the administration of ATS in the form of serum sickness (1.1% of the persons given ATS injections) and anaphylactic shock considerably exceeded the value of negative results of the infection. In the presence of immune population (over 86% of the children and 82% of adults are immune) and with additional vaccination of definite groups it is not only possible, but necessary to suspend ATS injections in trauma; instead, 0.5 ml of tetanus toxoid should be used for revaccination. Suspension of ATS application in trauma gives marked economy of the budget of the public health of the region.
在北方泰加林土壤植被区及更往北的地区，使用抗破伤风血清（ATS）并不适宜，因为土壤中破伤风杆菌的污染程度较低，且当地居民与土壤的接触很少。在阿尔汉格尔斯克地区，外伤发生率高但破伤风发病率低，以血清病形式（接受ATS注射者的1.1%）和过敏性休克形式给予ATS给居民造成的损害，大大超过了感染未发生的价值。在有免疫人群（超过86%的儿童和82%的成年人有免疫力）且对特定群体进行额外疫苗接种的情况下，不仅可以，而且有必要暂停对外伤患者注射ATS；相反，应使用0.5毫升破伤风类毒素进行再接种。在外伤中暂停使用ATS，可为该地区公共卫生预算显著节省开支。
