Atkins Clarke E, Brown William A, Coats Julie R, Crawford Mary Ann, DeFrancesco Teresa C, Edwards Joel, Fox Philip R, Keene Bruce W, Lehmkuhl Linda, Luethy Michael, Meurs Kate, Petrie Jean-Paul, Pipers Frank, Rosenthal Steven, Sidley Jennifer A, Straus Justin
Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA.
J Am Vet Med Assoc. 2002 Sep 1;221(5):654-8. doi: 10.2460/javma.2002.221.654.
To determine the effect of long-term administration of enalapril on renal function in dogs with severe, compensated mitral regurgitation.
Randomized controlled trial.
139 dogs with mitral regurgitation but without overt signs of heart failure.
Dogs were randomly assigned to be treated with enalapril (0.5 mg/kg [0.23 mg/lb], PO, q 24 h) or placebo, and serum creatinine and urea nitrogen concentrations were measured at regular intervals for up to 26 months.
Adequate information on renal function was obtained from 132 dogs; follow-up time ranged from 0.5 to 26 months (median, 12 months). Mean serum creatinine and urea nitrogen concentrations were not significantly different between dogs receiving enalapril and dogs receiving the placebo at any time, nor were concentrations significantly different from baseline concentrations. Proportions of dogs that developed azotemia or that had a +/- 35% increase in serum creatinine or urea nitrogen concentration were also not significantly different between groups.
And Clinical Relevance: Results suggest that administration of enalapril for up to 2 years did not have any demonstrable adverse effects on renal function in dogs with severe, compensated mitral regurgitation.
确定长期给予依那普利对重度代偿性二尖瓣反流犬肾功能的影响。
随机对照试验。
139只患有二尖瓣反流但无明显心力衰竭迹象的犬。
将犬随机分为接受依那普利（0.5mg/kg[0.23mg/lb]，口服，每24小时一次）或安慰剂治疗组，并定期测量血清肌酐和尿素氮浓度，最长达26个月。
从132只犬获得了关于肾功能的充分信息；随访时间为0.5至26个月（中位数为12个月）。在任何时间，接受依那普利治疗的犬与接受安慰剂治疗的犬的平均血清肌酐和尿素氮浓度均无显著差异，且与基线浓度相比也无显著差异。两组之间出现氮质血症或血清肌酐或尿素氮浓度升高/降低35%的犬的比例也无显著差异。
结果表明，在重度代偿性二尖瓣反流犬中，给予依那普利长达2年对肾功能没有任何明显的不良影响。
