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视觉运动学习过程中皮质-纹状体有效连接性的变化

Changes of cortico-striatal effective connectivity during visuomotor learning.

作者信息

Toni Ivan, Rowe James, Stephan Klaas E, Passingham Richard E

机构信息

F.C. Donders Centre for Cognitive Neuroimaging, University of Nijmegen, NL-6500 HB Nijmegen, The Netherlands.

出版信息

Cereb Cortex. 2002 Oct;12(10):1040-7. doi: 10.1093/cercor/12.10.1040.

Abstract

It has been suggested that the cortico-striatal system might play a crucial role in learning behavioural plans of action. We have tested this hypothesis by studying the dynamics of functional coupling among the neural elements of cortico-striatal circuitry. Human cerebral activity was measured with functional magnetic resonance imaging (fMRI) during the learning of an associative visuomotor task. Structural equation modelling of regional fMRI time-series was used to characterize learning-related changes in effective connectivity. We report that learning to associate visual instructions with motor responses significantly altered cortico-striatal functional couplings. Specific learning-related increases of effective connectivity were found in temporo-striatal and fronto-striatal circuits. Connectivity among portions of the frontal cortex decreased as a function of learning. Temporo-frontal and parieto-frontal couplings were not altered during learning. We infer that novel visuomotor associations are established through the enhancement of specific cortico-striatal circuits, rather than through the alteration of direct temporo-frontal or parieto-frontal connectivity.

摘要

有人提出,皮质-纹状体系统可能在学习行为行动计划中发挥关键作用。我们通过研究皮质-纹状体回路神经元件之间功能耦合的动态变化来检验这一假设。在学习一项联想性视觉运动任务期间,使用功能磁共振成像(fMRI)测量人类大脑活动。利用区域fMRI时间序列的结构方程模型来表征与学习相关的有效连接变化。我们报告称,学习将视觉指令与运动反应相关联会显著改变皮质-纹状体功能耦合。在颞叶-纹状体和额叶-纹状体回路中发现了与学习相关的有效连接的特定增加。额叶皮质各部分之间的连接随着学习而减少。在学习过程中,颞叶-额叶和顶叶-额叶耦合没有改变。我们推断,新的视觉运动关联是通过增强特定的皮质-纹状体回路建立的,而不是通过改变直接的颞叶-额叶或顶叶-额叶连接来建立的。

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