Bo Jin, Lee Chi-Mei, Kwak Youngbin, Peltier Scott J, Bernard Jessica A, Buschkuehl Martin, Jaeggi Susanne M, Wiggins Jillian L, Jonides John, Monk Christopher S, Seidler Rachael D
1 School of Kinesiology, University of Michigan , Ann Arbor, Michigan.
Brain Connect. 2014 Apr;4(3):166-80. doi: 10.1089/brain.2013.0155. Epub 2014 Apr 4.
Distinctive cortico-striatal circuits that serve motor and cognitive functions have been recently mapped based on resting state connectivity. It has been reported that age differences in cortico-striatal connectivity relate to cognitive declines in aging. Moreover, children in their early teens (i.e., youth) already show mature motor network patterns while their cognitive networks are still developing. In the current study, we examined age differences in the frontal-striatal "cognitive" and "motor" circuits in children and adolescence, young adults (YAs), and older adults (OAs). We predicted that the strength of the "cognitive" frontal-striatal circuits would follow an inverted "U" pattern across age; children and OAs would have weaker connectivity than YAs. However, we predicted that the "motor" circuits would show less variation in connectivity strength across the lifespan. We found that most areas in both the "cognitive" and "motor" circuits showed higher connectivity in YAs than children and OAs, suggesting general inverted "U"-shaped changes across the lifespan for both the cognitive and motor frontal-striatal networks.
基于静息态连接性，最近已经绘制出了服务于运动和认知功能的独特皮质-纹状体回路。据报道，皮质-纹状体连接性的年龄差异与衰老过程中的认知衰退有关。此外，十几岁早期的儿童（即青少年）已经表现出成熟的运动网络模式，而他们的认知网络仍在发育中。在本研究中，我们考察了儿童、青少年、青年（YAs）和老年人（OAs）在额叶-纹状体“认知”和“运动”回路中的年龄差异。我们预测，“认知”额叶-纹状体回路的强度在整个年龄范围内将呈倒“U”形模式；儿童和老年人的连接性将比青年弱。然而，我们预测“运动”回路在整个生命周期内连接性强度的变化较小。我们发现，“认知”和“运动”回路中的大多数区域在青年中的连接性高于儿童和老年人，这表明认知和运动额叶-纹状体网络在整个生命周期中普遍呈现倒“U”形变化。
