Aractingi Sélim, Regnier Stéphanie
Unité de Dermatologie, Hôpital Tenon, 4, rue de la Chine, 75020 Paris, France.
Ann Med Interne (Paris). 2002 May;153(3):189-91.
Several studies have shown an association between the presence of systemic sclerosis in females and the presence of fetal cells in peripheral blood. These results have led to the hypothesis that systemic sclerosis (SSc) may indeed be the consequence of an allogeneic fetomaternal reaction. However, certain normal female controls also exhibit microchimerism. In addition, there are several clinical and histological differences between SSc and sclerodermoid graft versus host reaction. If microchimerism plays a role in SSc, it would therefore comprise one step in a multistep process. This review focuses on recent papers targeting microchimerism and its evaluation in SSc.
多项研究表明，女性系统性硬化症的存在与外周血中胎儿细胞的存在之间存在关联。这些结果引发了一种假说，即系统性硬化症（SSc）可能确实是同种异体母胎反应的结果。然而，某些正常女性对照也表现出微嵌合现象。此外，SSc与硬皮病样移植物抗宿主反应之间存在一些临床和组织学差异。因此，如果微嵌合现象在SSc中起作用，它将是多步骤过程中的一个步骤。本综述重点关注针对微嵌合现象及其在SSc中的评估的近期论文。
