Goldstein Neal S
Department of Anatomic Pathology, William Beaumont Hospital, Royal Oak, MI 48073, USA.
Am J Clin Pathol. 2002 Sep;118(3):425-34. doi: 10.1309/JMRD-W08Y-6K8M-7AD8.
Relationships between membrane E-cadherin reactivity of invasive carcinoma, a dyshesive growth pattern, and lobular carcinoma-type systemic metastases were studied in 295 breast carcinomas and 57 patients with lobular carcinoma systemic metastases. There were 143 pure lobular carcinomas, 80 mixed (lobular and ductal) carcinomas, and 72 pure ductal carcinomas. Two (7%) of 30 mixed, predominantly lobular carcinomas, 23 (61%) of 38 mixed carcinomas, and 8 (67%) of 12 mixed, predominantly ductal carcinomas had E-cadherin staining in more than 10% of the lobular carcinoma cells. Lobular carcinoma-type systemic metastases were identified in 45 cases (38 [84%], pure lobular; 5 (11%], mixed; 2 [4%], pure ductal). No E-cadherin staining was found in 42 (98%) of 43 lobular carcinomas in cases of lobular carcinoma-type sYstemic metastases and all 57 cases of lobular carcinoma systemic metastases. Absent cell-to-cell adhesion seems to be a necessary property of carcinoma cells to facilitate permeation through tissue planes and produce characteristic lobular carcinoma-type systemic metastases. The level of decreased E-cadherin expression at which a dyshesive growth pattern emerges in primary breast carcinomas may be less than the level associated with lobular carcinoma-type systemic metastases.
在295例乳腺癌和57例小叶癌全身转移患者中，研究了浸润性癌的膜E-钙黏蛋白反应性、分散性生长模式与小叶癌型全身转移之间的关系。其中有143例纯小叶癌、80例混合性（小叶和导管）癌和72例纯导管癌。30例以小叶为主的混合性癌中有2例（7%）、38例混合性癌中有23例（61%）、12例以导管为主的混合性癌中有8例（67%），其小叶癌细胞中E-钙黏蛋白染色超过10%。45例出现小叶癌型全身转移（38例[84%]为纯小叶癌；5例[11%]为混合性癌；2例[4%]为纯导管癌）。在43例小叶癌型全身转移病例中的42例（98%）小叶癌以及所有57例小叶癌全身转移病例中均未发现E-钙黏蛋白染色。细胞间黏附缺失似乎是癌细胞穿过组织平面并产生特征性小叶癌型全身转移的必要特性。原发性乳腺癌中出现分散性生长模式时E-钙黏蛋白表达降低的水平可能低于与小叶癌型全身转移相关的水平。
